DermKnowledgeBASE (DKB)


1. Get rules for a given disease

canAffect - OralMucosa
canAffect - Oral
canAffect - Scalp
canAffect - OralCavity
commonFeature - Plaque
commonFeature - Ulcerative
commonFeature - Plaques
commonFeature - Erosions
commonFeature - Acantholytic
hasAssociation - PemphigusVulgaris
hasAssociation - ParaneoplasticPemphigus
hasAssociation - Pustular
hasAssociation - DarierDisease
hasAssociation - PyostomatitisVegetans
hasInvestigation - DirectImmunofluorescence
hasInvestigation - Immunofluorescence
hasInvestigation - Biopsy
hasInvestigation - IndirectImmunofluorescence
type - DermCondition
type - Pemphigus

2. Get differentials for a given history
List of recognised terms.
Include known differential diagnosis as below


Pemphigus - 3920
BullousDrugReaction - 54
GeneralizedBullousFixedDrugEruption - 54
MultilocularBullousFixedDrugEruption - 54
BullousDrugEruption - 54
LinearIgaDermatosis - 54
PemphigusControlledBySulfapyridine - 54
LinearIgaBullousDermatosis - 54
HerpetiformPemphigus - 54
PemphigusHerpetiformis - 54
MixedBullousDisease - 54
AcantholyticHerpetiformDermatitis - 54
PyostomatitisVegetans - 52
IgaPemphigus - 42
OcularPemphigus - 42
DuhringDisease - 42
DermatitisHerpetiformis - 42
PemphigusVegetans - 42
Drug-inducedLichenPlanus - 42
LichenoidDrugEruption - 42
BenignMucosalPemphigoid - 42
PemphigusVulgaris - 42
ParaneoplasticPemphigus - 42
BenignMucousMembranePemphigoid - 42
ScarringPemphigoid - 42
CicatricialPemphigoid - 42
Drug-inducedLichenoidReaction - 42
KeratosisFollicularis - 40
DyskeratosisFollicularis - 40
WartyDyskeratoma - 40
FocalPalmoplantarKeratodermaWithOralMucosalHyperkeratosis - 40
DarierDisease - 40
DariersDisease - 40
HereditaryPainfulCallosities - 40
HereditaryPainfulCallositySyndrome - 40
NummularEpidermolyticPalmoplantarKeratoderma - 40
KeratosisPalmoplantarisNummularis - 40
FocalEpidermolyticPalmoplantarKeratoderma - 40
Darier–whiteDisease - 40
IsolatedDyskeratosisFollicularis - 40
GestationalPemphigoid - 32

3. Get differentials for a given disease


BenignMucousMembranePemphigoid - 67
SolitaryLichenoidKeratosis - 67
LichenoidKeratosis - 67
BenignLichenoidKeratosis - 67
LichenSclerosusEtAtrophicus - 67
LichenPlanus-likeKeratosis - 67
SolitaryLichenPlanus - 67
LichenSclerosus - 67
OcularPemphigus - 67
BenignMucosalPemphigoid - 67
CicatricialPemphigoid - 67
ScarringPemphigoid - 67

4. Get synonyms for a given disease



5. Annotate a body of text with terms from ONTODerm


However, very little is known about the pathophysiological processes underlying rhinoscleroma [1]. We present a case of rhinoscleroma in a 51-year-old Egyptian immigrant with 1-month history of epistaxis [2]. In on case, the infiltrating histiocytes had large Round or Oval nuclei [3]. The diagnosis of extranodal RDD in the paranasal sinuses could be differentiated with rhinoscleroma, eosinophilic granuloma, plasmacytoma, or fibrous histiocytoma [4]. We observed two cases of rhinoscleroma in the Souro-Sanou university hospital of Bobo-Dioulasso, Burkina Faso, over a 9-year period (2009Â to 2010) [5]. The diagnosis of rhinoscleroma should be considered for any obstructive Tumor of the nasal fossae [6]. Emperipolesis and S-100-positive histiocytes confirm the diagnosis of Rosai-Dorfman disease [7]. The light-staining bands were formed by aggregates of large Round or Polygonal histiocytes with emperipoiesis [8]. Immunohistochemical study showed that the histiocytes strongly expressed S-100 protein and partially expressed CD68 [9]. RDD can easily mimic rhinoscleroma, mainly due to the overlapping morphologic appearance [10]. Genome-wide linkage analysis and whole-exome sequencing identified a homozygous frameshift deletion in SLC29A3, which encodes human equilibrative nucleoside transporter-3 (hENT3) [11]. Because identification of the etiologic agent is crucial for the definitive diagnosis of the disease, the aim of this study was to develop two simple PCR assays [12]. We took advantage of the fact that all Klebsiella pneumoniae subsp [13]. The K3-specific sequence of gene Kr11509 (wzy) was exploited to set up a PCR test, which was positive for 40 K3 strains but negative when assayed on the 76 other Klebsiella capsular types [14]. Infection by the bacterium Klebsiella rhinoscleromatis is said to be the cause [15]. The antigen was extracted from Klebsiella rhinoscleromatis Rh32 by the trichloroacetic acid and separated by ethanol (Boivin method) [16]. The concentrations of IgA, IgG and IgM Antibodies were expressed as optical density (OD) measured at the wavelength of 450 nm [17]. The cut-off limit of serum Antibodies was set at mean Antibody OD determined in the sera of 30 blood donors exceeded by three standard deviations [18]. Histopathological examination showed characteristic Mikulicz histiocytes containing numerous Gram-negative intracellular rod-shaped bacilli consistent with the diagnosis of rhinoscleroma [19]. It is important to consider rhinoscleroma in cases of Chronic nasal obstruction [20]. In the past, rhinoscleroma was infrequent in the Spanish population but, with current trends in migration, the incidence of rhinoscleroma may be on the rise [21]. Six histochemical stains, including PAS, Giemsa, Gram, methylene blue, modified Warthin-Starry and acid-fast stains were applied [22]. Both pharyngeal treponemal infection and infection by rhinoscleroma bacilli could be detected by modified Warthin-Starry stain [23]. A diagnosis of a Granulomatous process, including rhinoscleroma, was initially discussed [24]. The correct diagnosis was made histologically by demonstrating aggregates of histiocytes with large amounts of cytoplasm, emperipolesis and protein S100 antigen expression [25]. The diagnosis is made based on the histological presence of large histiocytes with lymphophagocytosis [26]. Two unrelated consanguineous families were identified, 1 of which included 2 affected siblings [27]. She had a three-year history of treatment for asthma and a history of operation for a Nasal Mass that afflicted her for 15 years and was diagnosed as rhinoscleroma [28]. A provisional diagnosis was made after clinical assessment and radiological investigations, but final diagnosis was made after histopathological examination [29]. All the cases were carefully examined histopathologically and it was found that the region was affected by a variety of non-neoplastic lesions [30]. Among 240 cases, 145 were non-neoplastic and 95 were neoplastic The lesions in the decreasing order of frequency were - Nasal polyp, rhinoscleroma, tuberculosis, fungal infection, fibrous Dysplasia, ossifying fibroma, Cysts, nasal glioma, and cemento-ossifying fibroma


This is an experimental application for healthcare professionals. The information presented here is not intended to diagnose, treat, cure or prevent any disease. Read disclaimer. - Evidence based skincare free

About Me

I have varied research interests ranging from eHealth, Health Information Exchange, Clinical Trials and Research, Contact Dermatitis, Bioinformatics, and Cosmetic Dermatology. I have work experience in Canada as an eHealth analyst, and in Dubai and India as a Specialist Dermatologist.


Bell Raj Eapen
Hamilton, ON