DermKnowledgeBASE: telangiectasia


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The text is the summary of recent articles on telangiectasia at 75 thresold from National Library of Medicine (NLM). This information is subject to NCBI's Disclaimer and Copyright notice.

Irradiated bovine aortic endothelial Cells showed increased eNOS transcription and NO generation through upregulation of ataxia-telangiectasia mutated (ATM) kinase [1]. ATM kinase has been established as a central player in DNA double-strand break repair and its deficiency causes ataxia telangiectasia, a rare, multi-system disease with no cure [2]. Atm tamoxifen-inducible mouse models were generated to explore whether Atm reconstitution is able to restore Atm function in an Atm-deficient background [3]. The total Number of treatments with intranasal bevacizumab injection was 210 [4]. Skin Biopsy was consistent with telangiectasia macularis eruptiva perstans (TMEP) [5].

The telangiectasias appeared at two months of age and followed a Progressive course [6]. Recent guidelines, however, recommended that the sole presence of telangiectasias should not form the basis of a distinct variant of CM [7]. Using the same methods, the synergy between Anacardic acid and 5-Fluorouracil or Gemcitabine was determined [8]. Chromatin Modifying Protein 1A (Chmp1A), Ataxia Telangiectasia Mutated (ATM), and p53 were the primary signaling molecules examined [9]. In spheroid formation assays, spheroids formed were smaller in size and in Number upon Anacardic acid treatment compared to control [10].

This article will review the most common Vascular liver diseases associated with hepatocellular Nodules (Budd-Chiari syndrome, congenital portosystemic shunt, hereditary hemorrhagic telangiectasia, and portal cavernoma) [11]. Our study confirms disturbances in redox homeostasis in AT and NBS patients and indicates a need for diagnosing oxidative stress in those cases as a potential disease biomarker [12]. Thirty-five Han Chinese patients with facial or Hand Hyperpigmentation and telangiectasia due to second-degree fire burns received treatment with IPL [13]. Blood flow in telangiectasia skin was measured by laser Doppler flow [14]. Doppler showed a significant decreased blood flow in telangiectasia after treatment [15].

Loss-of-function Mutations in ALK1 cause a subtype of hereditary hemorrhagic telangiectasia-a rare disease characterized by vasculature malformations [16]. These results were confirmed in cutaneous telangiectasia biopsies of patients with hereditary hemorrhagic telangiectasia 2, in which we also detected an increase in endothelial cell proliferation linked to an increase on the PI3K pathway [17]. Previous case reports suggest its efficacy in preventing gastrointestinal bleeding (GIB) secondary to angiodysplasia (AD) in hereditary haemorrhagic telangiectasia and potentially in reversing AD [18]. When HPV-positive Cells are treated with hydroxyurea, this recruitment of RAD51 and BRCA1 to viral genomes is greatly enhanced with little recruitment to damaged cellular DNAs and with retention of the ability of viral genomes to amplify [19]. Replication of high-risk HPVs requires the activation of the ataxia telangiectasia-mutated (ATM) and ATM- and Rad3-related (ATR) DNA repair pathways [20].

A growing body of work has uncovered an autonomous role for Eng in endothelial Cells [21]. ataxia-telangiectasia commonly results in a spectrum of movement disorders beyond ataxia and telangiectasias [22]. Using human prostate cancer samples and two human prostate cancer cell lines (LNCaP and DU145), Tip60 protein expression and the acetylation of ataxia telangiectasia mutant (ATM) were analysed by western blotting and immunoprecipitation [23]. Oxidative stress, mitochondrial damage and cell death were studied with live-cell Microscopy and flow cytometry [24]. Combined Efavirenz and radiation significantly increased the Number of γH2AX and phospho-ataxia telangiectasia mutated foci [25].

In the pine needle oil-treated HepG2 Cells, the protein levels of phosphorylated (p)-ataxia-telangiectasia mutated (ATM), γ-H2A histone family, member X, p-p53, p-checkpoint kinase 2 and p-cell division cycle 25C were evidently increased, indicating that pine needle oil facilitated G2/M arrest in HepG2 Cells through the ATM pathway [26]. In FANCC-/- mice, BMF during Multiple emergency granulopoiesis attempts was associated with increased ataxia telangiectasia and Rad3-related protein (Atr) and p53 activation with each attempt [27]. She was found to have annular and Discoid Plaques with prominent overlying telangiectasia [28]. Levels of histone H2AX phosphorylation (γ-H2AX) were determined by immunohistochemistry and ataxia telangiectasia mutated(ATM) protein levels were measured by western blot analysis [29]. No clinically meaningful changes were observed in skin blanching, inflammatory lesions, or telangiectasia [30].

Finally, DNA damage was confirmed by the activation of the ataxia telangiectasia mutated serine/threonine kinase (ATM)-checkpoint kinase 2 (Chk2) signaling pathway [31]. Endoscopic evaluation mainly showed erythema and telangiectasia [32]. The miR-199a-3p and miR-10b-5p targets were validated by qRT-PCR, western blot and luciferase target assays [33]. The effects of miR-199a-3p and miR-10b-5p on DNA repair were determined by evaluating the activation of the protein kinases ataxia-telangiectasia mutated (ATM), ataxia telangiectasia and Rad3-related (ATR) and the serine 39 phosphorylation of variant histone H2AX (γH2AX) as indirect measure of double-strand DNA breaks (DSB) in irradiated FRTL-5 CL2 Cells [34]. Interestingly, the overexpression of miR-10b-5p decreases the viability of the irradiated FRTL5-CL2 and 8505c cell lines [35].

Here we report a chain of events triggered by Multiple splicing factor Mutations, especially high-risk alleles in SRSF2 and U2AF1, including elevated R-loops, replication stress, and activation of the ataxia telangiectasia and Rad3-related protein (ATR)-Chk1 pathway [36]. A significant association was noted between longer disease duration and higher odds of Pulmonary Hypertension, telangiectasia, and calcinosis [37].

References: 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ,

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I have varied research interests ranging from eHealth, Health Information Exchange, Clinical Trials and Research, Contact Dermatitis, Bioinformatics, and Cosmetic Dermatology. I have work experience in Canada as an eHealth analyst, and in Dubai and India as a Specialist Dermatologist.


Bell Raj Eapen
Hamilton, ON