( SLISE(Summary) - Drag this link to bookmarks bar for instant search)
The text is the summary of recent articles on staphylococcal scalded skin syndrome at 75 thresold from National Library of Medicine (NLM). This information is subject to NCBI's Disclaimer and Copyright notice.
After the acute Exfoliation of skin surface, Erythematous cellulitis occurs . Immediate medication with parenteral anti-staphylococcal Antibiotics is mandatory . Traditionally, frozen section has been used in dermatology to diagnose toxic Epidermal necrolysis, with some additional utility in staphylococcal scalded skin syndrome in the new born period . We report a newborn Female with ruptured Bullae on the Face, Chest, back and Extremities with a clinical differential diagnosis that included staphylococcal scalded skin, bullous congenital ichthyosiform erythroderma/epidermolytic Hyperkeratosis and epidermolysis bullosa . Aureus M060 isolated from a patient with staphylococcal scalded skin syndrome showed higher cytotoxic activity toward host Cells than that shown by MVs from three other clinical S .
Aureus MVs contained δ-hemolysin (Hld), γ-hemolysin, leukocidin D, and exfoliative Toxin C, but exfoliative Toxin A (ETA) was specifically identified in S . Despite restarting the antibiotic therapy immediately the initial Lesion expanded, and Disseminated flaccid blisters on an Erythematous base appeared within a few hours . In the primary Lesion an ETA-producing Staphylococcus aureus strain was isolated . Possible causes include lower Antibody levels against exfoliative toxins and Renal immaturity . The subject of this report is unique in that he developed the largest Exfoliation described in literature .
Part I of this 2-part continuing Medical education article addresses common pitfalls involving site selection and Biopsy technique in the diagnosis of bullous diseases, Vasculitis, Panniculitis, connective tissue diseases, drug eruptions, graft-versus-host disease, staphylococcal scalded skin syndrome, Hair disorders, and neoplastic disorders . (vancomycin-sensitive) developed in blood cultures performed on the day of death (seventh day), and Pseudomonas aeruginosa and Serratia marcescens were identified in cultures on nasopharyngeal, Buttock and abdominal secretions . From Neck of each mouse was isolated and identified endogenous exfoliative producing strain of S . (vancomycin-sensitive) developed in blood cultures performed on the day of death (seventh day), and Pseudomonas aeruginosa and Serratia marcescens were identified in cultures on nasopharyngeal, Buttock and abdominal secretions . The disease presents as a painful cutaneous rash that culminates with the detachment of the superficial Dermis .
The usual treatment is Antibiotics with beta-lactamase resistant penicillin . Detailed epidemiological and microbiological investigations were undertaken . All eight isolates contained genes encoding exfoliative Toxin A (eta) and six of them contained genes encoding Toxin B (etb) . Common among these are acute and Chronic graft-versus-host disease, erythema multiforme, Stevens-Johnson syndrome/toxic Epidermal necrolysis, Eruption of lymphocyte recovery, staphylococcal scalded skin syndrome, morbiliform drug eruptions, infections, and toxic erythema of Chemotherapy . A 51-year-old man receiving Chemotherapy for leukemia presented with a large geographic Erosion with superficial sloughing and multiple smaller lesions elsewhere .
The diagnosis can be confirmed by a Skin Biopsy specimen, which can be expedited by frozen section processing, as staphylococcal scalded skin syndrome should be distinguished from life threatening toxic epidermal necrolysis . Histologically, the superficial epidermis is detached, the separation level being at the granular Layer . The exfoliative toxins are spread haematogenously from a Localized source of infection, causing widespread Epidermal damage at distant sites . Recent epidemiological studies have demonstrated that paediatric patients have an increased incidence of staphylococcal scalded skin syndrome during the summer and autumn . A 64-year-old man was admitted to our hospital with a high fever and Generalized exfoliative dermatitis .
Population Distribution, historical features, physical examination findings including laboratory tests, antibiotic therapies, and outcomes were evaluated . The genome-wide SNPs that were ascertained revealed the evolutionary history of CC121, indicating at least six major clades (A to F) within the clonal complex and dating its most recent common ancestor to the pre-antibiotic era . All isolates evidently sampled from superficial infections (including staphylococcal scalded skin syndrome, bullous impetigo, exfoliative dermatitis, conjunctivitis) Clustered in clade F, which included the European epidemic fusidic-acid resistant impetigo clone (EEFIC) . Aureus clonal complex, and that SNPs serve as powerful discriminatory markers, able to identify these lineages . In this clinical lesson, we present a case of acute skin detachment in a Newborn caused by staphylococcal scalded skin syndrome (SSSS) .
Generalised superficial Erosions on the Face, Hands and Feet arose within hours . Based on the clinical presentation combined with a subcorneal Blister found on histopathological examination and a positive culture for Staphylococcus aureus on nasal and umbilical smears, the diagnosis of SSSS was made . The staphylococcal scalded skin syndrome is an acute Exfoliation of the skin caused by exfoliative toxins A and B . Bien que le Staphylococcus aureus soit une cause fréquente d’infection des brûlures, la SSSS suite à une infection brûlure est rare . Le Staphylococcus aureus a été isolé qui provenait des brûlures dans les deux cas .
References: 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 ,Press Refresh to fetch fresh content with references from pubmed. This content was cached on 2017-06-20 comments powered by Disqus
This is an experimental application for healthcare professionals. The information presented here is not intended to diagnose, treat, cure or prevent any disease. Read disclaimer.