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The text is the summary of recent articles on nevus depigmentosus at 75 thresold from National Library of Medicine (NLM). This information is subject to NCBI's Disclaimer and Copyright notice.
The major differential diagnoses are the postinflammatory hypomelanoses for nonsegmental vitiligo and nevus depigmentosus for segmental vitiligo . The etiopathogenesis in not fully understood, although a defect in the transfer of melanosomes from Melanocytes to keratinocytes has been reported . The association between nevus depigmentosus and nevus spilus is extremely rare, as the incidence, as well as the etiopathogenesis of this Unilateral coexistence of such double presented pigmented disorder is unknown, due to the limited literature data reported as an example of twin spotting . We present an unusual case of nevus depigmentosus in association with nevus spilus . Moreover, extracutaneous findings, particularly serious neurologic defects, have been reported in a large Number of these cases .
The Hypopigmentation is permanent and enlarges in proportion with growth in the person . In vivo reflectance confocal Microscopy (RCM) is a noninvasive technique for real-time en Face imaging of the superficial layers of the skin down to the superficial Dermis with cellular level resolution close to conventional histopathology . In vivo reflectance confocal Microscopy (RCM) is a non-invasive, repetitive imaging tool that provides real-time images at a nearly cellular histological resolution . In addition, part of the Dermal Papillary rings showed lack of integrity or their brightness decreased in adjacent normal-appearing skin in all the patients of the AVP . In all the patients with nevus depigmentosus, the content of melanin decreases obviously but the Dermal Papillary rings are intact .
Atopy, xerosis, and mineral deficiencies are potential risk factors . Poor cutaneous hydration appears to be a common theme for most risk factors and may help elucidate the pathogenesis of this disorder . The end result of this mechanism is inappropriate melanosis manifesting as Hypopigmentation . It must be differentiated from other disorders of Hypopigmentation, such as pityriasis versicolor alba, vitiligo, nevus depigmentosus, and nevus anemicus . An 11-year-old boy presented with two distinct types of hypopigmented lesions, one on the Forehead and the other on his back .
The first was a Hypopigmented Patch with leukotrichia, and it was incidentally discovered 3 months before the Child was examined at our clinic and it had rapidly increased in size . The second Hypopigmented Patch was detected at birth and it had slowly been increasing in size . Simultaneously, the melanin was distributed heterogeneously in the Dermal Papillary rings . Thus, it is sometimes difficult to differentiate vitiligo from nevus depigmentosus only by clinical features . The number of Melanocytes was also decreased in nevus depigmentosus but not as much as in vitiligo .
How gender and maturity of newborns affect presentation and prevalence of Vascular birthmarks, in particular, has not been well documented . Although the distinction between the two diseases is important, differential diagnosis relies on Medical history and physical examination, which is far from decisive in some cases . There have been many reports of colocalization of ND and lentigines . We describe development of multiple lentigines over ND in a 9-year-old girl along with hypoplasia of the underlying breast . An 18-yr-old Korean man with segmental nevus depigmentosus developed Multiple Pigmented nevi which were present only within the confines of the leukoderma .
Histologic and electron microscopic studies rendered a diagnosis of nevus depigmentosus with dysplastic nevus to the patient . When it is systematized, it is indistinguishable from hypomelanosis of ito . Histopathologic studies showed that the staining ability of Fontana-Masson in nevus depigmentosus lesions decreased compared with perilesional normal skin . However, there were no changes in the numbers of Melanocytes identified as S-100-positive Cells in the basal Layer . Histologically these lesions are hypopigmented chronic Dermatitis .
Although the lesions are arranged in a lichen striatus pattern, they differ clinically from lichen striatus by the absence of papules and Plaques . The differential diagnosis includes lichen striatus, vitiligo, piebaldism, nevus depigmentosus, and hypomelanosis of Ito . Pigmentary anomalies along the lines of Blaschko, including hypomelanosis of ito, Linear and whorled nevoid hypermelanosis, and nevus depigmentosus, can be associated with notable abnormal Systemic features .
References: 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ,Press Refresh to fetch fresh content with references from pubmed. This content was cached on 2017-09-13 comments powered by Disqus
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