DermKnowledgeBASE: Stevens johnson Syndrome

Stevens johnson Syndrome

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The text is the summary of recent articles on Stevens johnson Syndrome at 75 thresold from National Library of Medicine (NLM). This information is subject to NCBI's Disclaimer and Copyright notice.

Any Surgical intervention in a hostile ocular surface environment may worsen the disease, which may result in visual deterioration [1]. Hereby, we present the case of a 73-year-old Chinese male who suffered from DRESS and other complications two weeks after initiating VPA treatment for epilepsy [2]. Carbamazepine with the rare SNP allele of rs3909184 causing Stevens Johnson syndrome, and aminoglycosides with rs267606617 causing sensory neural deafness [3]. They represent true medical emergencies and an early recognition and appropriate management is decisive for the survival [4]. The diagnosis of different degrees of Epidermal necrolysis is based on the clinical assessment in conjunction with the corresponding histopathology [5].

Today, the severity-of-illness score for toxic Epidermal necrolysis (SCORTEN) is available for SJS/TEN severity assessment [6]. However, many factors contributing to Epidermal necrolysis still have to be identified, especially in virus-induced and autoimmune forms of Epidermal necrolysis not related to drugs [7]. Stevens-Johnson syndrome was the most frequent clinical subtype of severe cutaneous adverse drug reactions [8]. There is also evidence of association of certain HLA alleles with lamotrigine (LTG)-induced cADRs, but this has not been reported in the Indian population [9]. All reported patients had laboratory confirmed enterovirus infection [10].

Four Children (three males) developed gynaecomastia, two developed hypercholesterolaemia, and one Child developed Stevens-Johnson syndrome [11]. Results: Between 1999 and 2014, 86 cases of hospitalized patients with diagnosis of Stevens-Johnson syndrome and toxic epidermal necrolysis in the Federal District were reported [12]. A similar, more severe form of the disorder included in this spectrum is toxic epidermal necrolysis (TEN) [13]. Five adverse event groups (anaphylaxis, syncope, Stevens-Johnson syndrome, adverse effect of drug, and respiratory failure) met criteria for manual Medical record review [14]. Only two serious ADRs (including one Stevens-Johnson syndrome case) occurred [15].

Stevens-Johnson syndrome/toxic Epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and Mucosal loss accompanied by Systemic symptoms [16]. We present the case of an HIV positive 28-year-old-man, , with secondary syphilis, who developed a Stevens Johnson Syndrome (SJS) caused by one of the many drugs he was receiving [17]. Unlike Stevens-Johnson syndrome or toxic Epidermal necrolysis, AGEP is rarely life-threatening [18]. He presented with rash and Fever several weeks after introduction of lamotrigine, having been on valproic acid for seizure disorder [19]. Patients with SJS/TEN were assessed clinically using the SCORe of Toxic Epidermal Necrosis (SCORTEN) Scale [20].

In most patients with aqueous-deficient dry Eye, pharmaceutical tear substitutes are used to control symptoms and prevent ocular surface damage [21]. However, in severe dry Eye conditions caused by cicatricial disorders, such as Stevens-Johnson syndrome and ocular cicatricial mucous membrane pemphigoid, noninvasive treatments are insufficient, and patients are at risk of developing complications that can lead to blindness [22].

References: 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ,

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I have varied research interests ranging from eHealth, Health Information Exchange, Clinical Trials and Research, Contact Dermatitis, Bioinformatics, and Cosmetic Dermatology. I have work experience in Canada as an eHealth analyst, and in Dubai and India as a Specialist Dermatologist.


Bell Raj Eapen
Hamilton, ON