DermKnowledgeBASE: Stevens johnson Syndrome

Stevens johnson Syndrome

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The text is the summary of recent articles on Stevens johnson Syndrome at 75 thresold from National Library of Medicine (NLM). This information is subject to NCBI's Disclaimer and Copyright notice.


Hence, AGEP is known to have a good prognosis and to be life-threatening only in elderly patients or patients with Chronic diseases [1]. Both of our patients responded well to corticosteroids and one of them required intravenous immunoglobulin [2]. He presented with rash and Fever several weeks after introduction of lamotrigine, having been on valproic acid for seizure disorder [3]. Treg migration toward epithelial Cells is regulated by certain chemokines, including TARC/CCL17 and MDC/CCL22 [4]. Patients with SJS/TEN were assessed clinically using the SCORe of Toxic Epidermal Necrosis (SCORTEN) Scale [5].

In most patients with aqueous-deficient dry Eye, pharmaceutical tear substitutes are used to control symptoms and prevent ocular surface damage [6]. However, in severe dry Eye conditions caused by cicatricial disorders, such as Stevens-Johnson syndrome and ocular cicatricial mucous membrane pemphigoid, noninvasive treatments are insufficient, and patients are at risk of developing complications that can lead to blindness [7]. By contrast, little is known about the shared and unique enhancer regulatory mechanisms in different ectodermally derived epithelial Cells [8]. Furthermore, we found that two SNPs previously linked to corneal diseases, astigmatism and Stevens-Johnson syndrome, fall within corneal epithelial enhancers and alter their activity by disrupting transcription factor motifs that overlap these SNPs [9]. In Ikzf1 Tg, we observed Dermatitis and mucosal Inflammation including the ocular surface [10].

A cyclic Recurrence of her symptoms was noted, and the diagnosis of autoimmune progesterone dermatitis was made by an intradermal progesterone challenge [11]. The use of immunosuppressive agents such as Corticosteroids and intravenous immunoglobulin (IVIg) is controversial [12]. Recent studies have revealed that the prevalence of SJS/TEN is associated with genetic backgrounds, such as polymorphisms in human leukocyte antigens (HLAs) [13]. Although most cases are mild, some patients have extrapulmonary complications including mucocutaneous Eruptions including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and erythemamultiforme (EM) [14]. The SCORTEN score (SCORe of Toxic Epidermal Necrosis) for establishing the seriousness is 1 [15].

References: 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 ,

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