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Stevens johnson Syndrome

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The text is the summary of recent articles on Stevens johnson Syndrome at 75 thresold from National Library of Medicine (NLM). This information is subject to NCBI's Disclaimer and Copyright notice.

Forty patients (29 female) had experienced different hypersensitivity reactions due to AEDs: Maculopapular exanthema (26 patients), Stevens-Johnson syndrome (6 patients), drug rash with eosinophilia and systemic symptoms (7 patients), toxic Epidermal necrolysis (1 patient) [1]. Toxic Epidermal necrolysis, Stevens-Johnson syndrome, and Multiform Exudative erythema are part of the same disease spectrum [2]. The pathophysiology of toxic Epidermal necrolysis is similar in many respects to that of superficial skin burns [3]. It is generally accepted that patients with toxic epidermal necrolysis are better treated in burn units, which are experienced in the management of patients with extensive skin loss [4]. La necrolisis epidérmica tóxica, el síndrome de Steven Johnson y el eritema exudativo multiforme forman parte del mismo espectro de enfermedad [5].

La fisiopatología de la necrolisis epidérmica tóxica es semejante en muchos aspectos a la de las quemaduras dérmicas superficiales [6]. Se acepta en General que los pacientes con necrolisis epidérmica tóxica son tratados mejor en unidades de grandes quemados, donde existe experiencia en el manejo de enfermos con pérdida cutánea extensa [7]. She had no history of vaccine-related rash or other adverse drug reactions, nor had she received any other drug therapy [8]. The Temporal relationship between the development of SJS and the vaccination suggests that the rabies vaccination probably was the causal agent [9]. toxic Epidermal necrolysis and Stevens-Johnson syndrome/toxic Epidermal necrolysis overlap syndrome were associated with longer stay, greater mortality, and higher hospital charges than those with Stevens-Johnson syndrome [10].

Subsequent quadrivalent inactivated influenza vaccine was well tolerated [11]. Sulphonamide antibiotics are commonly accepted as one of the primary causes of SJS/TEN [12]. We further quantified absolute risks of SJS/TEN within separate cohorts of antibiotic users and assessed causality in each exposed case using an adapted version of the algorithm of drug causality in Epidermal necrolysis (ALDEN) [13]. We retrospectively analyzed 10 cases that consisted of 6 males and 4 females, which comprised 7 adenocarcinomas, 2 squamous cell carcinomas and one Pleomorphic Carcinoma [14]. One of these AEs was severe (Stevens-Johnson syndrome grade 4) but could be treated by steroid pulse therapy, steroid ointment and instillation [15].

The characteristic histological findings of erythema multiforme (EM), Stevens-Johnson syndrome (SJS), and toxic Epidermal necrolysis (TEN) provide conclusive evidence demonstrating that SJS/TEN can be distinguished from EM [16]. Hereby, we present the case of a 73-year-old Chinese male who suffered from DRESS and other complications two weeks after initiating VPA treatment for epilepsy [17]. Carbamazepine with the rare SNP allele of rs3909184 causing Stevens Johnson syndrome, and aminoglycosides with rs267606617 causing sensory neural deafness [18]. They represent true medical emergencies and an early recognition and appropriate management is decisive for the survival [19]. The diagnosis of different degrees of Epidermal necrolysis is based on the clinical assessment in conjunction with the corresponding histopathology [20].

Today, the severity-of-illness score for toxic Epidermal necrolysis (SCORTEN) is available for SJS/TEN severity assessment [21]. However, many factors contributing to Epidermal necrolysis still have to be identified, especially in virus-induced and autoimmune forms of Epidermal necrolysis not related to drugs [22]. Stevens-Johnson syndrome was the most frequent clinical subtype of severe cutaneous adverse drug reactions [23]. There is also evidence of association of certain HLA alleles with lamotrigine (LTG)-induced cADRs, but this has not been reported in the Indian population [24]. All reported patients had laboratory confirmed enterovirus infection [25].

Four Children (three males) developed gynaecomastia, two developed hypercholesterolaemia, and one Child developed Stevens-Johnson syndrome [26]. Results: Between 1999 and 2014, 86 cases of hospitalized patients with diagnosis of Stevens-Johnson syndrome and toxic epidermal necrolysis in the Federal District were reported [27]. A similar, more severe form of the disorder included in this spectrum is toxic epidermal necrolysis (TEN) [28]. Five adverse event groups (anaphylaxis, syncope, Stevens-Johnson syndrome, adverse effect of drug, and respiratory failure) met criteria for manual Medical record review [29]. Only two serious ADRs (including one Stevens-Johnson syndrome case) occurred [30].

Stevens-Johnson syndrome/toxic Epidermal necrolysis is a rare, acute, serious, and potentially fatal skin reaction in which there are sheet-like skin and Mucosal loss accompanied by Systemic symptoms [31]. We present the case of a 28-year-old-man, HIV positive, with secondary syphilis, who developed a Stevens Johnson Syndrome (SJS) caused by one of the many drugs he received [32]. Unlike Stevens-Johnson syndrome or toxic Epidermal necrolysis, AGEP is rarely life-threatening [33].

References: 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ,

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I have varied research interests ranging from eHealth, Health Information Exchange, Clinical Trials and Research, Contact Dermatitis, Bioinformatics, and Cosmetic Dermatology. I have work experience in Canada as an eHealth analyst, and in Dubai and India as a Specialist Dermatologist.


Bell Raj Eapen
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