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Solitary Neurofibroma

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The text is the summary of recent articles on Solitary Neurofibroma at 75 thresold from National Library of Medicine (NLM). This information is subject to NCBI's Disclaimer and Copyright notice.

The patient consequently received a Roux-en-Y hepaticojejunostomy and was confirmed with neurofibroma pathologically [1]. They occur rarely in the gastro-intestinal tract as isolated neoplasms, outside the classical clinical feature of neurofibromatosis [2]. We herein present an isolated colonic neurofibroma without any Systemic signs of neurofibromatosis [3]. This case report describes an unusual presentation of solitary neurofibroma on the lingual gingiva of the mandibular posterior region of a 22-year-old Woman [4]. Based on the histopathologic findings, a final diagnosis of neurofibroma was made [5].

The patient underwent left subtotal Temporal bone resection, and histological and immunohistochemical findings confirmed the lesion to be a neurofibroma [6]. Treatment of Localized and Diffuse neurofibromas is often surgical resection, which may require sacrifice of the nerve [7]. Solitary neurofibromas of the male genital tract are exceedingly rare Benign peripheral nerve sheath neoplasms composed of Schwann Cells and fibroblasts [8]. Histopathology report identified the Mass consistent with neurofibroma [9]. He exhibited no skin Pigmentation, no hearing deficit, and no evidence suggestive of any Systemic disorders that might have been attributable to the Tongue base neurofibroma [10].

Thus, a diagnosis of isolated neurofibroma of the Tongue was established [11]. We report a case of a 55-year-old Female with no history of neurofibromatosis who presented with a slow-growing, Painless lump on her torso [12]. She was diagnosed with solitary Subcutaneous neurofibroma with features of Malignant peripheral nerve sheath Tumor transformation [13]. Although mostly associated with neurofibromatosis, it can be Solitary [14]. solitary neurofibroma may occur in deep soft tissue or Subcutaneous plane in rare cases associated with syndromes like NF1 [15].

The neurofibroma most commonly present as skin lesions as isolated soft Papules or Nodules arising in any cutaneous site [16]. They can be Solitary or may be associated with neurofibromatosis type-1 (NF-1) [17]. This work also discusses the various differential diagnoses that can be considered in similar cases [18]. Other Benign tumours included inverted papilloma, squamous papillomas and extrapleural solitary neurofibroma Tumor [19]. Neurofibromas are usually found in individuals with neurofibromatosis, which is an Autosomal dominant disease [20].

Although solitary neurofibroma that occurs in the paranasal sinus is reported occasionally, neurofibroma located in the frontal sinus is extremely rare [21]. Here, we report a case of a young Woman who had a heterogeneous Lesion in the left frontal sinus, eroding its anterior and posterior wall with signs of intracranial invasion [22]. Postoperatively, results of the histologic examination confirmed the diagnosis of solitary neurofibroma [23]. We also report a case of a solitary neurofibroma of the gingiva in a 72-year-old male of 15 years duration [24]. Generally, a solitary neurofibroma is located in the skin and rarely in other places [25].

Histological examination revealed gastric adenocarcinoma, invading the Mucosa without nodal Metastasis, and a neurofibroma [26]. We present an unusual case of anterior knee Pain in an Adult patient from a solitary neurofibroma arising in an intra-articular location associated with the infrapatellar fat pad [27]. Clinical, radiographic, magnetic resonance imaging (MRI), and histopathologic features are presented, as well as, a review of the literature [28]. We present a case of frontal sinus neurofibroma treated successfully with Surgical Excision [29]. Histopathological examination showed the Tumor to be a neurofibroma [30].

We studied the effect of this modality on a giant solitary neurofibroma of the Neck [31]. Three months post-PDT, MRI revealed a significant reduction in the neurofibroma size [32]. Solitary Subungual neurofibroma appears to be a rare condition [33]. Up until now, less than 10 case reports of Solitary Subungual neurofibroma have been documented [34]. Solitary Subungual neurofibroma is difficult to diagnose, particularly as it is often small and without obvious symptoms [35].

A 19-year-old male with no known history of a neurofibromatosis presented with a Painless swelling in the left forearm [36]. Histological evaluation proved the Nodular Structure was an MPNST component completely surrounded by neurofibroma [37]. Pre-operative imaging gave useful information about the extent of the Mass which was then totally excised with histology revealing a non-plexiform neurofibroma [38]. The patient underwent Surgical Excision of the Mass and histopathologic examination confirmed the diagnosis of a neurofibroma [39]. This case is the first reported instance of aspiration cytologic diagnosis of intrascrotal neurofibroma [40].

The disorder may be associated with a variety of clinical manifestations including both superficial and deep-seated lesions such as café-au-lait spots, skinfold freckling, Lisch Nodules, and cutaneous, deeper, and visceral neurofibromas, Visceral involvement, in particular, rarely affects the Genital tract, and isolated ovarian neurofibromas are extremely rare [41]. After Surgical Excision of the neurofibroma, he had no Pain and a normal sensation of the penile glans, and his erectile dysfunction improved [42].

References: 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 ,

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I have varied research interests ranging from eHealth, Health Information Exchange, Clinical Trials and Research, Contact Dermatitis, Bioinformatics, and Cosmetic Dermatology. I have work experience in Canada as an eHealth analyst, and in Dubai and India as a Specialist Dermatologist.


Bell Raj Eapen
Hamilton, ON