DermKnowledgeBASE: Seborrheic


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The text is the summary of recent articles on Seborrheic at 75 thresold from National Library of Medicine (NLM). This information is subject to NCBI's Disclaimer and Copyright notice.

We report a case of a previously healthy 59-year-old Woman who underwent electrocoagulation to remove seborrheic keratosis confirmed by dermatoscopy [1]. Multiple dermatologic conditions may mimic erythematotelangiectatic rosacea [2]. The most commonly reported cases occur in patients with atopic dermatitis [3]. There was one incidental finding of a seborrheic Keratosis on breast skin [4]. seborrheic dermatitis is a similar Scalp skin disorder with aggravated Itchy rashes and flaking [5].

In this report, we extend our previous investigation aimed at identifying the presence of active β-HPV infection in skin Tumors from KTRs through detection of viral protein expression [6]. These infected tissues displayed intraepidermal Hyperplasia and increased expression of the ΔNp63 protein, which extended into the upper epithelial layers [7]. In the latter, both β-HPV infection and ΔNp63 expression were no longer detectable [8]. These findings will help in the histopathological diagnosis as well as to understand the histogenesis of sweat Gland neoplasms [9]. Design: This was an interventional, open-label, safety and efficacy study [10].

Of interest, two samples with strong FISH signals also showed MCPyV expression as tested by IHC [11]. To date, there have been no standardized or quantified diagnostic criteria defining the Sign of Leser-Trelat, but instead, the colloquial definition includes an increase in the Number and/or size of the seborrheic keratoses [12]. This “sign” has been met with a significant amount of skepticism by many considering the commonality of both seborrheic keratoses and malignancy in elderly patients [13]. The Sign of Leser-Trelat was first described by in the 1800s by Edmund Leser and Ulysse Trelat, but instead of eruptive seborrheic keratoses, they were studying the presence of cherry angiomas in oncology patients [14]. The Number of dermatologic manifestations was significantly greater in patients with CD4 count less than 200/mm3 or in stage C of the CDC classification [15].

The clinical manifestations of DD are characterized by Warty Papules and Plaques in seborrheic areas, and association with neuropsychiatric abnormalities has also been reported in a few families with DD [16]. Clinicians are frequently presented with a challenge when determining whether to remove a seborrheic keratosis, and which treatment modality to use when doing so [17]. We sought to analyze dermoscopy use in US Dermatology residencies to better understand resident dermoscopy utilization and teaching modalities [18]. We found residents learn dermoscopy via Multiple teaching modalities [19]. The most commonly reported dermoscopy teaching modality was didactic lectures, followed by time in clinic with a dermoscopy expert [20].

Of the different teaching modalities, time in the clinic with a dermoscopy expert was reported to be the most effective [21]. This is the first study to use whole exome sequencing to screen the ATP2A2 gene in a cohort of 28 clinically diagnosed darier disease patients [22]. Narrow-band ultraviolet-B phototherapy appears to be a very effective and safe treatment option for patients with severe seborrheic dermatitis [23].

References: 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ,

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About Me

I have varied research interests ranging from eHealth, Health Information Exchange, Clinical Trials and Research, Contact Dermatitis, Bioinformatics, and Cosmetic Dermatology. I have work experience in Canada as an eHealth analyst, and in Dubai and India as a Specialist Dermatologist.


Bell Raj Eapen
Hamilton, ON