DermKnowledgeBASE: Pyogenic Granuloma

Pyogenic Granuloma

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The text is the summary of recent articles on Pyogenic Granuloma at 75 thresold from National Library of Medicine (NLM). This information is subject to NCBI's Disclaimer and Copyright notice.

Sequencing did not identify a BRAF V600E Mutation in any of the 28 sporadic pyogenic granulomas, including 13 on the Eyelid [1]. We present a case of ulcerated Swelling of palate clinically diagnosed as pyogenic granuloma which presented a diagnostically challenging histological picture [2]. They often pose diagnostic challenges due to their overlapping clinical and histopathological features [3]. The differential diagnoses of AM include Acral Naevus, pyoderma gangrenosum, pyogenic Granuloma, verrucous carcinoma and peripheral neuropathy-induced foot ulcers [4]. If there is a clinical suspicion of AM, an excisional Biopsy should be taken [5].

A clinical diagnosis of pyogenic granuloma was entertained but the Lesion failed to respond to conservative therapy and eventually necessitated amputation of his thumb [6]. Its pathogenesis is still unclear while well-formed capillaries, pale stroma, bland fibroblast-like Cells, and multiple tiny spicules of woven Bone constitute the histological hallmarks [7]. Volume increases, for instance, were positively correlated to plasma cell epulis, pyogenic granuloma, fibrous reactive Hyperplasia and hemangioma [8]. Here, the authors report a case of a primigravida who presented an extragingival pyogenic granuloma with a rapid progression in the post-partum [9]. All specimens were analyzed by immunohistochemical staining with hematoxylin and eosin for the following hormones: estrogen receptor, progesterone receptor, VEGF, and EGFR [10].

They are commonly mistaken for other growths, such as pyogenic granuloma and fibroma, and diagnosis is accurately based on its distinctive histopathology [11]. This article presents the clinicopathologic findings of a 15-year-old Hispanic male presenting for biopsy of a melanotic Macule on the mandibular anterior buccal gingiva [12]. It represents a diagnostic challenge, as it is frequently misdiagnosed as dermatological Lesion [13]. There is a broad differential diagnosis, including pyogenic granuloma, cutaneous tuberculosis or congenital malformations, among others [14]. In fact eccrine poroma in the postauricular area has only been rarely reported [15].

Histological examination showed distinct features, and eccrine poroma was diagnosed [16]. The frequency of eccrine poroma is dependent on eccrine sweat glands density, and thus, usually occurs on the palms or Soles [17]. The typical clinical picture of this infection is characterized by asymptomatic flesh-colored, single or Multiple Papules, measuring 2-6 mm in diameter with a central umbilication that occur on the skin and the mucous membranes [18]. Surprisingly, today, 10 years after their completion, these RCTs still remain unpublished, whereas the corresponding FDA site provides no information with regard to the researchers, the centers in which these trials were conducted, their research protocol, and the demographic data of the enrolled patients [19]. However, little is known about the molecular pathogeneses and useful immunohistochemical markers of angiosarcoma [20].

To investigate the mechanisms of angiosarcoma progression, we collected 85 cases of human angiosarcoma specimens with clinical records and analyzed ISO-HAS-B patient-derived angiosarcoma Cells [21]. As control subjects, 54 cases of hemangioma and 34 of pyogenic granuloma were collected [22]. However, survivin expression modes and YAP localization (Hippo pathway activation modes) were not correlated with survival [23]. Tumor resection, followed by histological and immunohistochemical analysis, leads to the diagnosis and initiation of the proper treatment regimen [24]. Herein, immunohistochemistry showed an unequivocal profile in SGC and did not allow for an exact differentiation from BCC and SCC by immunohistochemical means only [25].

References: 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ,

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About Me

I have varied research interests ranging from eHealth, Health Information Exchange, Clinical Trials and Research, Contact Dermatitis, Bioinformatics, and Cosmetic Dermatology. I have work experience in Canada as an eHealth analyst, and in Dubai and India as a Specialist Dermatologist.


Bell Raj Eapen
Hamilton, ON