DermKnowledgeBASE: Phycomycosis


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The text is the summary of recent articles on Phycomycosis at 75 thresold from National Library of Medicine (NLM). This information is subject to NCBI's Disclaimer and Copyright notice.

The typical Lesion was a discoid Subcutaneous Mass that can be easily lifted from deeper tissues (the doughnut lifting sign) [1]. Supersaturated solution of potassium iodide was curative in 11 cases while addition of itraconazole was needed in one case [2]. The patient presented with Subcutaneous Swelling in the Midline of the forehead, dorsum of the nose, adjoining Cheek area (more on the right side), philtrum, and upper Lip [3]. Biopsy taken from the right nostril area revealed nasofacial phycomycosis [4]. Biopsy of the Lesion confirmed the diagnosis of Subcutaneous phycomycosis [5].

A case of a controlled diabetic male with rhino maxillary mucormycosis, with cerebral extension, is described [6]. Here we report 8 cases of rhinoentomophthoromycosis caused by Conidiobolous coronatus and 7 cases of Chronic Subcutaneous phycomycosis caused by Basidiobolus ranarum [7]. We present a very rare case of invasive mucormycosis (phycomycosis) occurring in the base of a chronic gastric Ulcer in a 55 years old diabetic male [8]. All the extracts at 1:10 dilution inhibited the growth of Basidiobolus haptosporus and B [9]. Subcutaneous phycomycosis is a chronic, Progressive fungal infection of the deeper layers of the human skin that causes Localized, mobile, firm and non-tender swellings [10].

In this patient, diagnosis was based on the presence of a characteristic bifocal deformation of the central region of the Face and on histological findings typical of rhinophycomycosis entomophtorae [11]. Numerous predisposing risk factors are associated with mucormycosis, although most cases have been reported in poorly controlled diabetics or in patients with hematologic Malignant conditions [12]. The rhino-sinuso-orbital presentation is typically observed in insulin-dependent diabetes mellitus with ketoacidosis [13]. Hyperbaric oxygen has theoretical value in treating mucormycosis, since it reduces tissue hypoxia caused by the Vascular insufficiency [14]. (he had previously received 2900 mg) and hyperbaric oxygen was added as adjunctive treatment [15].

The common fungi seen are candida, aspergillus and mucormycosis [16]. Common to all forms of mucormycosis is Vascular invasion with production of Necrotic tissue [17]. Clinical features resembled those of invasive aspergillosis or phycomycosis [18]. Despite treatment with amphotericin B the patient remained Febrile [19]. A review of the literature found only 9 cases of phycomycosis with localized cerebral involvement [20].

This report describes the sixth occurrence of phycomycosis in an intravenous drug addict (the fifth to localize in the basal ganglia) [21]. The onset of periorbital Inflammation, ophthalmoplegia, and Nasal turbinate or sinus invasion and Necrosis is consistent with phycomycosis [22]. In a medically stable patient an aggressive diagnostic approach, at times including stereotaxic brain aspirate or Biopsy, is indicated [23].

References: 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ,

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I have varied research interests ranging from eHealth, Health Information Exchange, Clinical Trials and Research, Contact Dermatitis, Bioinformatics, and Cosmetic Dermatology. I have work experience in Canada as an eHealth analyst, and in Dubai and India as a Specialist Dermatologist.


Bell Raj Eapen
Hamilton, ON