DermKnowledgeBASE: Neurilemmoma


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The text is the summary of recent articles on Neurilemmoma at 75 thresold from National Library of Medicine (NLM). This information is subject to NCBI's Disclaimer and Copyright notice.

Ancient schwannoma is a relatively rare variant of schwannoma, characterized by increased cellularity and atypia [1]. Surgical Excision was performed and the Pathology confirmed the diagnosis of ancient schwannoma [2]. The increased cellularity and atypia of ancient schwannoma can resemble features of malignancy [3]. Most of the literature, reports of schwannomas in the Tongue region are common [4]. In this article we report a rare occurrence of schwannoma in the maxillary alveolus region and its management [5].

Such a rare cas e of intraoral schwannoma should be followed up periodically to look for any Malignant transformation and recurrences [6]. All patients were pathologically confirmed as neurilemmoma after operation [7]. During the follow-up, the internal fixation in all patients receiving internal fixation of spine was stable with no vertebral instability [8]. Posterior laminectomy can achieve satisfactory clinical outcomes in the treatment of intraspinal neurilemmoma [9]. Objectives  Here, a systematic review was conducted to include 15 cases of patients with schwannoma of the base of the Tongue [10].

Overall, the histological studies were consistent with a Benign schwannoma with a palisading Antoni A and Antoni B pattern without Malignant changes in cell morphology [11]. Herein, we sought to identify molecular targets for therapy by using targeted RNA/DNA sequencing and gene expression of key immunological players [12]. We present a clinicopathological description of this rare variant of schwannoma, located in an unusual intraoral site, of a 26-year-old Female [13]. Moreover, she did not have a family history or symptoms associated with neurofibromatosis-1 (NF-1) [14]. The mechanisms by which SMARCB1 germline Mutations predispose to rhabdoid Tumors versus schwannomas are still unknown [15].

By inducing Smarcb1 loss at later developmental stage in the Schwann cell lineage, in addition to biallelic Nf2 gene inactivation, we generated the first mouse model developing schwannomas with the same underlying gene Mutations found in schwannomatosis patients [16]. SMARCB1 mutations predispose to rhabdoid Tumors and schwannomas but the mechanisms underlying the Tumor type specificity are unknown [17]. The most common Symptom associated with vagus nerve schwannoma arising in the Neck is hoarseness due to vocal cord palsy [18]. Histopathology showed a Benign spindle cell Tumor with Antoni A areas with palisading cell nuclei and some degenerative change, confirming the diagnosis of vagus nerve schwannoma [19]. CONCLUSIONS Vagus nerve schwannomas should be distinguished from other Tumors that arise in the neck before planning Surgery, to minimize the risk of nerve injury [20].

The aim of this case report was to present the Excision of a large jugular foramen schwannoma via the retrosigmoid approach and to describe the improvement of sensorineural Hearing Loss related to arachnoid inflammations due to Chronic arachnoiditis after suboccipital craniectomy [21]. Juxtaarticular Cysts encroaching on the hypoglossal canal were extradural, were contiguous with a craniocervical junction synovial joint, and showed thin rim enhancement [22]. The patient subsequently underwent excisional Surgery, and neuropathological evaluation of the specimen confirmed the diagnosis of Benign schwannoma with Antoni areas A and B [23]. Multiple schwannomas and/or meningiomas are more frequently associated with a Tumor suppressor syndrome and, accordingly, trigger genetic testing, whereas Solitary Tumors do not [24]. Clinical evidence indicates that schwannoma is Painless and slow growing [25].

Mutational inactivation of the NF2 gene encoding the protein Merlin is found in most sporadic and inherited schwannomas, but the molecular mechanisms underlying neoplastic changes in schwannoma Cells remain unclear [26]. We report here that Nf2-deficient Cells display elevated expression levels of key enzymes involved in lipogenesis and that this upregulation is caused by increased activity of Torc1 [27]. Schwannoma of the salivary Gland is a particularly rare form of an extracranial neurogenic Tumor, of which ancient schwannoma is one of five variants [28]. Since the first description, only a few ancient schwannomas have been reported in different locations in the Head and Neck region [29]. Radiological evidence demonstrating displacement of blood vessels may aid diagnosis of schwannoma [30].

Malignant transformation of ancient schwannoma has been reported [31].

References: 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ,

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