DermKnowledgeBASE: Neurilemmoma

Neurilemmoma

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The text is the summary of recent articles on Neurilemmoma at 75 thresold from National Library of Medicine (NLM). This information is subject to NCBI's Disclaimer and Copyright notice.


All patients were pathologically confirmed as neurilemmoma after operation [1]. During the follow-up, the internal fixation in all patients receiving internal fixation of spine was stable with no vertebral instability [2]. Posterior laminectomy can achieve satisfactory clinical outcomes in the treatment of intraspinal neurilemmoma [3]. The patient subsequently underwent excisional Surgery, and neuropathological evaluation of the specimen confirmed the diagnosis of Benign schwannoma with Antoni areas A and B [4]. Multiple schwannomas and/or meningiomas are more frequently associated with a Tumor suppressor syndrome and, accordingly, trigger genetic testing, whereas Solitary Tumors do not [5].

Clinical evidence indicates that schwannoma is Painless and slow growing [6]. Mutational inactivation of the NF2 gene encoding the protein Merlin is found in most sporadic and inherited schwannomas, but the molecular mechanisms underlying neoplastic changes in schwannoma Cells remain unclear [7]. We report here that Nf2-deficient Cells display elevated expression levels of key enzymes involved in lipogenesis and that this upregulation is caused by increased activity of Torc1 [8]. Radiological evidence demonstrating displacement of blood vessels may aid diagnosis of schwannoma [9]. Malignant transformation of ancient schwannoma has been reported [10].

Intracranial schwannomas tend to manifest on the eighth cranial nerve, particularly in patients with neurofibromatosis type2 [11]. Eligible patients were aged 18 years or older with localised, high-risk (high malignancy grade, 5 cm or longer in diameter, and deeply located according to the investing fascia), soft-tissue Sarcoma of the Extremities or trunk wall and belonging to one of five histological subtypes: high-grade myxoid liposarcoma, leiomyosarcoma, synovial Sarcoma, Malignant peripheral nerve sheath tumour, and undifferentiated Pleomorphic Sarcoma [12]. Here, we investigated the possibility of using cytotoxic T Cells to treat malignant Schwannoma, a rare but aggressive nerve sheath Tumor, by examining the native T-cell immunity in the host [13]. In addition, we present the findings of an adolescent woman surgically managed for intracavernous CN VI schwannoma [14].

References: 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ,

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