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The text is the summary of recent articles on Mikulicz Disease at 75 thresold from National Library of Medicine (NLM). This information is subject to NCBI's Disclaimer and Copyright notice.
Steroid therapy can reverse the inflammatory changes in IgG4 hypophysitis . So differential diagnosis is important and essential as to the salivary gland swelling . In this paper, we analyzed a case of a 59-year-old male with Symmetric salivary Gland Swelling . Physical examination showed skin, sclera yellow dye, swollen submandibular, sublingual and lacrimal Gland and splenomegaly . We describe an unusual presentation of IgG4 disease with isolated diabetes insipidus secondary to pituitary hypophysitis .
This disease frequently affects the pancreas, salivary glands and lymph nodes, but can involve almost any tissue . Six Oral and maxillofacial radiologists randomly reviewed the arranged image sets under blinded conditions . It presents a distinctive histopathological appearance of dense lymphoplasmacytic infiltrates with abundant IgG4-positive plasma Cells, storiform Fibrosis and obliterative phlebitis with the appearance of Inflammatory Swelling or tumefactive lesions . Published by Oxford University Press on behalf of the British Society for Rheumatology . Recent investigations have also raised the possibility that innate immunity might precede adaptive immunity, thus further complicating the pathological scenario .
In this study, we examined the diagnostic utility of submandibular gland (SMG) and labial salivary Gland (LSG) biopsies in IgG4-DS . Published by Oxford University Press on behalf of the British Society for Rheumatology . Type 1 is related to immunoglobulin G4 and type 2 is related to granulocytic epithelial lesions, but pathogenetic mechanisms in both still remain unclear . In contrast, labial salivary Gland (LSG) Biopsy is more convenient . However, little is known about its pathogenesis and pathological condition .
Surgical Excision is recommended in order to treat the Tumor and to ensure the pathological diagnosis . At this three-week follow-up, the patient reported no discomfort and his swollen salivary glands, Neck lymph node and pancreas had returned to normal size . Corticosteroid treatment significantly suppresses relapse in patients with autoimmune pancreatitis showing a relatively high rate of spontaneous remission . Long-term observational studies have demonstrated the transformation of autoimmune pancreatitis into Chronic pancreatitis presenting with pancreatic Atrophy and stone formation .
References: 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 ,Press Refresh to fetch fresh content with references from pubmed. This content was cached on 2017-10-12 comments powered by Disqus
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