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The text is the summary of recent articles on Michelin Tire Baby Syndrome at 75 thresold from National Library of Medicine (NLM). This information is subject to NCBI's Disclaimer and Copyright notice.
The disease phenotype comprises characteristic circumferential skin creases accompanied by intellectual disability, a cleft palate, short stature, and dysmorphic features . In those reported with this phenotype who had skin biopsies, Pathology has shown nevus lipomatosis, smooth muscle hamartoma, degenerative collagen, and Scarring . Many individuals with the MTB phenotype have had a variety of other congenital anomalies . I review the literature on MTB and the history of the designation michelin tire baby syndrome (MTBS) . We report a case of michelin tire baby syndrome with congenital panhypopituitarism .
The Infant had Generalized excessive folding of skin and facial dysmorphism . In some patients however, the circumferential skin creases are associated with other congenital malformations . We describe 2 unrelated patients presenting with Multiple circumferential skin creases, growth retardation, developmental delay, a typical facial appearance and Cleft Palate . Skin Biopsy demonstrated increased smooth Muscle fibers in the deeper Dermis . Similar clinical manifestations shared by our patient and a boy reported previously suggest a new clinical entity, in which degenerative collagen is etiologically involved .
Other abnormalities included: short stature, loose skin, hypotonia, pectus excavatum, inguinal and umbilical hernias, severe scoliosis, hypoplastic scrotum, long fingers and overlapping toes .
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