DermKnowledgeBASE: Kaposi Sarcoma

Kaposi Sarcoma

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The text is the summary of recent articles on Kaposi Sarcoma at 75 thresold from National Library of Medicine (NLM). This information is subject to NCBI's Disclaimer and Copyright notice.


Activation of mammalian target of rapamycin (mTOR), platelet-derived growth factor (PDGF), Vascular endothelial growth factor (VEGF), and c-kit signaling pathways has been implicated in KS pathogenesis and may suggest a role for targeted inhibitors [1]. It can be categorized in numerous ways, such as unicentric versus multicentric, histopathological variants (hyaline-vascular, plasma cell, and mixed), or subtypes based on causative viral infections (human Immunodeficiency virus, human herpesvirus-8, or kaposi sarcoma herpesvirus) [2]. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, New York [3]. Novel phenotypic features include endemic Kaposi sarcoma (KS), furrowed tongue, thoracolumbar scoliosis, and mild mitral valve Dysplasia [4]. (2)Departments of Hematology, Rheumatology, and Infectious Disease, Kumamoto University Graduate School of Medicine, Honjo, Kumamoto, Japan [5].

A defining property of PEL is its consistent association with kaposi sarcoma associated herpesvirus (KSHV) infection, and, in most cases, Epstein Barr virus (EBV) co-infection [6]. The other histological differential diagnoses of KHE include infantile haemangioma, congenital haemangioma, spindle cell haemangioma, verrucous malformation/haemangioma, and kaposi sarcoma [7]. The patient in this case had extensive pulmonary and endobronchial kaposi sarcoma (KS) that led to complete consolidation of the right lung that was diagnosed via bronchoscopy [8]. Germinotropic lymphoproliferative disorder is a rare disorder, with only 6 cases reported in the literature [9]. We have previously demonstrated that the proteasome inhibitor Bortezomib inhibits NF-κB pathway, which is required for Tumor maintenance in endothelial Cells that express vGPCR (vGPCR cells) [10].

In this work, we further investigated Bortezomib anti-proliferative mechanism of action [11]. One session was sufficient for small lesions, whereas coalescing and multicentric lesions required up to 4 sessions [12].

References: 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ,

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