DermKnowledgeBASE: Kaposi Sarcoma

Kaposi Sarcoma

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The text is the summary of recent articles on Kaposi Sarcoma at 75 thresold from National Library of Medicine (NLM). This information is subject to NCBI's Disclaimer and Copyright notice.

HHV-8 immunostaining may aid in the differential diagnosis with kaposi sarcoma while epithelioid hemangioendothelioma can be distinguished based on morphologic features [1]. They include human papillomavirus (HPV)-associated carcinomas, Epstein-Barr virus (EBV)-associated tumors, Merkel cell polyomavirus (MCPyV)-related merkel cell carcinoma, and Human Herpesvirus 8 (HHV8)-related kaposi sarcoma [2]. Calcineurin Inhibitors (CNIs) such as Cyclosporine and Tacrolimus are immunosuppressive agents given after solid organ transplantation, but they can also promote Tumor growth [3]. Biopsy specimens of 11 HIV-related, 7 non-HIV-related kaposi sarcoma (KS), and 7 normal skin tissues (NSTs) of Dutch origin were analyzed [4]. RNA was isolated from the paraffin material, and gene expression levels of IL-32 α, β, and γ isoforms, IL1a, IL1b, IL6, IL8, TNFA, PTGS2, CXCR1, and PTK2 were determined using real-time quantitative PCR [5].

Significantly higher expression of IL-32β and IL-32γ isoforms was observed in HIV-related KS Biopsy specimens compared with non-HIV-related KS and NST [6]. Renal transplant involvement is rare, whereas Renal transplant parenchymal involvement causing transplant dysfunction is exceptionally rare [7]. Lymphomas are perhaps the cancer type that is most closely associated with oncogenic viruses: infection with EBV, human T-lymphotropic virus 1 (HTLV-1), human Immunodeficiency virus (HIV), Kaposi sarcoma-associated herpesvirus/human herpesvirus 8, and hepatitis c virus have all been associated with lymphomagenesis [8]. Immune reconstitution inflammatory syndrome has been well described for a host of mycobacterial, viral, and fungal OIs and malignancies such as kaposi sarcoma [9]. This applies to infection-related cancers such as kaposi sarcoma, Burkitt lymphoma, Hodgkin lymphoma and hepatocellular Carcinoma, and also to two common embryonal cancers - retinoblastoma and nephroblastoma [10].

Since the discovery over 50 years ago of the Epstein-Barr virus as the cause of Burkitt lymphoma, seven other human viruses or groups of viruses-hepatitis B virus, hepatitis c virus, human immunodeficiency virus type 1, some human papillomaviruses, human T-cell lymphotropic virus type 1, Kaposi sarcoma-associated herpesvirus and Merkel cell polyomavirus-have been linked to human cancer [11]. Are co-inventors on a patent application related to the treatment of kaposi sarcoma by pomalidomide and the material in this manuscript [12].

References: 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ,

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About Me

I have varied research interests ranging from eHealth, Health Information Exchange, Clinical Trials and Research, Contact Dermatitis, Bioinformatics, and Cosmetic Dermatology. I have work experience in Canada as an eHealth analyst, and in Dubai and India as a Specialist Dermatologist.


Bell Raj Eapen
Hamilton, ON