DermKnowledgeBASE: Infundibular Cyst

Infundibular Cyst

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The text is the summary of recent articles on Infundibular Cyst at 75 thresold from National Library of Medicine (NLM). This information is subject to NCBI's Disclaimer and Copyright notice.

In this particular case, the location, overlying skin changes, and rapid growth of the Lesion raised suspicion for malignancy [1]. Previous reports found that it may be occasionally associated with Gardner syndrome [2]. Neither extra-intestinal manifestation nor a family history of Gardner syndrome was found in any case [3]. A natural language search of the CoPath database across the institution was undertaken using the diagnosis of Sebaceous Cyst, epidermal cyst, epidermoid cyst, epithelial Cyst, infundibular cyst, pilar cyst, trichilemmal cyst, and steatocystoma [4]. The Koebner Phenomenon is defined as the appearance of cutaneous lesions on previously noninvolved skin following trauma and is observed in a series of cutaneous diseases including psoriasis, lichen planus, viral warts, molluscum contagiosum, etc [5].

In this case report, 3 patients with longstanding MF are presented, the 1st with the appearance of a circumscribed early-stage type MF Lesion rapidly following a Surgical Excision of an infundibular Cyst, the 2nd with the appearance of a unique Unilateral palmar tumoral MF Lesion at the pressure site of a crutch, and the 3rd presented localized MF early stage lesions at the friction site of a belt [6]. Cystic trichoblastoma is a unique type of trichoblastoma, which originates from the Cyst walls of an infundibular cyst (usually) or steatocystoma/hybrid Cyst (rarely) [7]. They are felt to be caused by an abnormality at the infundibular level of the vellus Hair [8]. The lesions showed a configuration similar to infundibular Cysts, including basophilic orthokeratotic corneocytes arranged in basket-weave pattern and intermingled with Eosinophilic sebum [9]. In addition, transgenic mice hemizygous-null for nm23-m1 and nm23-m2 exhibited UVR-induced melanoma and follicular infundibular cyst formation, and tumor-associated Melanocytes displayed invasion into adjacent Dermis, consistent with loss of invasion-suppressing activity of NM23 in vivo [10].

Cutaneous leishmaniasis is usually characterized by a single, polymorphous Lesion located in an uncovered area [11]. The disease was characterized by a single, asymptomatic nodule, which was clinically diagnosed as an Inflammatory infundibular cyst [12]. Although Benign, numerous pathological processes, including Benign and Malignant Tumors, inflammatory dermatoses, and certain infectious entities, have been reported to occur within the epithelial lining of infundibular Cysts [13]. The four false positives (3/4 confirmed pathologically) included an infundibular cyst, an inflamed supraclavicular Cyst, pneumonitis, and degenerative disc disease [14]. Therefore so-called FCH has much in common with the newly described late stage of trichofolliculoma, which also exhibits an infundibular cyst and Sebaceous and follicular differentiation with various signs of catagen and telogen [15].

Comparing our 8 cases of FCH and 31 cases of trichofolliculoma, we came to the conclusion that FCH is the very late stage of trichofolliculoma [16]. In spite of the well known regressive changes of normal Hair follicles during catagen and telogen, the possibility of corresponding changes in the trichofolliculoma has not yet been discussed in the literature [17]. Histological examination showed a circumscribed dermal Nodule composed of Sebaceous lobules attached to Sebaceous ducts and to an infundibular cyst-like Structure connected to the epidermis [18]. Histopathologic examination of the Biopsy specimens showed in all cases an intradermal infundibular cyst lined by a papillated and/or digitated epithelium with focal prominent Hypergranulosis and irregular keratohyalin granules [19]. The neoplasms differ from other variants of basal cell Carcinoma by being situated on the Face only, being small and well circumscribed, and having signs of follicular differentiation, namely, numerous tiny infundibular cyst-like structures and aggregations of neoplastic Cells that resemble Hair follicles in telogen [20].

References: 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 ,

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I have varied research interests ranging from eHealth, Health Information Exchange, Clinical Trials and Research, Contact Dermatitis, Bioinformatics, and Cosmetic Dermatology. I have work experience in Canada as an eHealth analyst, and in Dubai and India as a Specialist Dermatologist.


Bell Raj Eapen
Hamilton, ON