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The text is the summary of recent articles on I-cell Disease at 75 thresold from National Library of Medicine (NLM). This information is subject to NCBI's Disclaimer and Copyright notice.
We report the progression of polysomnographic abnormalities in a Child with mucolipidosis II, demonstrated by worsening sleep-related hypoventilation, OSA, and sleep state fragmentation despite advancing PAP therapy . Subsequent cardiac catheterization confirmed atresia of the left main coronary artery . The patient underwent Cardiac Surgery with coronary artery bypass grafting of the left internal mammary artery to the left anterior descending coronary artery . Repeat Cardiac catheterization revealed stenosis of the right Proximal coronary artery, raising concern for progressive coronary involvement . These cargo molecules follow the secretory pathway, which is a vital part of cellular trafficking machinery in all eukaryotic Cells .
Here, we describe and illustrate various radiological-musculoskeletal manifestations of a rare case of mucolipidosis II who has been a survivor up to now, 20 years old . Our case demonstrates several skeletal features of dysostosis multiplex . It has remained unresolved, however, whether acid hydrolase binding is required for exit of the CI-MPR from the TGN . These data show that there is no block in TGN exit of the CI-MPR in the absence of Man-6-P-modified acid hydrolases . Most cargo is sorted within, and exits from, the trans-Golgi network (TGN) .
An 11-month-old Child presented with abnormal Head Shape, developmental delay and bent Bones . We report here pathological findings of an autopsy case of mucolipidosis type ii . The patient was an 8-year-old boy with mucolipidosis type ii and was complicated with hypertrophic cardiomyopathy . He suddenly developed Progressive respiratory failure and finally died . Niemann-Pick disease-C (NPC) was confirmed by fibroblasts study using filipin stain .
This disease is usually found to occur in individuals aged between 6 and 12 months, with a clinical phenotype resembling that of hurler syndrome and radiological findings resembling those of dysostosis multiplex . At birth, the patient had characteristic features of ML II, and skeletal radiographs revealed dysostosis multiplex, similar to rickets . The second patient had a much better outcome because of prompt diagnosis and was able to undergo Bone marrow transplant as a result . This method describes the derivatization of oligosaccharides present in urine with phenyl-1-methylpyrazolone, which renders them hydrophobic, thus allowing desalting with Combi cleanup columns prior to injection . A model system, consisting of cultured skin fibroblasts from patients with mucopolysaccharidoses (MPS), showed that their defective glycosaminoglycan catabolism could be corrected by factors derived from Cells of a different genotype .
For this reason we developed a mixed mode liquid chromatography tandem Mass spectrometry assay for the screening of the oligosaccharidoses which potentially mitigates many of the problems associated with thin layer chromatography . MLII is an Autosomal recessive disease with a carrier rate estimated at 1/39 in Saguenay-Lac-Saint-Jean (SLSJ) (Quebec, Canada), which is the highest frequency documented worldwide . The Bone disease in these patients is believed to be due to hyperparathyroidism . Here, we applied the Qproteometrade mark GlycoArray kit to perform glycan analysis of heparanase, and compared the kit results with the more commonly used biochemical analyses . Iodinated heparanase has been utilized to calculate binding affinity .
Here we report on an adolescent with progressive joint contractions and other signs of mucolipidosis II who survived to the age of 14 years . The activities of serum alkaline phosphatase and parathyroid hormone were markedly elevated . We conclude that early skeletal manifestation of mucolipidosis type ii is not clearly identified and that differentiation from congenital rickets or congenital hyperparathyroidism could be difficult . These six patients exhibited a wide spectrum of clinical abnormalities, in particular shortened extremities: they included three patients with unknown causes of clinical symptoms, one patient with Sanfilippo disease, one of the seven patients with achondroplasia, and one with hypophosphotemic rickets . The oligosaccharides were referenced against the internal standard, methyl lactose, to produce ratios for comparison with control samples .
This case expands the phenotypic spectrum of mucolipidosis type ii . No useful markers were identified for krabbe disease, MPS II, Pompe disease, and Sandhoff disease .
References: 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 ,Press Refresh to fetch fresh content with references from pubmed. This content was cached on 2017-12-31 comments powered by Disqus
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