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Fifth Disease

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The text is the summary of recent articles on Fifth Disease at 75 thresold from National Library of Medicine (NLM). This information is subject to NCBI's Disclaimer and Copyright notice.


It can also cause an aplastic crisis in those with certain anemias, hydrops fetalis in pregnant Women, polyarthropathy, and papular-purpuric gloves and socks syndrome (PPGSS) in young adults [1]. A fever is likely to occur with roseola, erythema infectiosum (fifth disease), and scarlet Fever [2]. The important clinical manifestations are erythema infectiosum or the fifth disease, transient aplastic anemia in patients with hemoglobinopathies, acute polyarthralgia syndrome in adults, hydrops fetalis, spontaneous abortion and stillbirth [3]. An outbreak of erythema infectiosum was observed from December 2001 to September 2002, with the peak frequency in April and May 2002 and 39 diagnosed cases, and stable Number of cases from 2005 to 2009 (a total of 49 diagnosed cases) [4]. Besides cephalhematoma, petechial rashes were present on his Trunk and limbs [5].

The initial laboratory tests were essentially normal, including platelet count and coagulation tests [6]. Expanded laboratory tests were repeated to explore the etiology of his skin Hemorrhage, all of which indicated that hematological disorders were unlikely [7]. Both Autosomal Dominant and autosomal recessive traits were observed, without any clear difference in clinical phenotype or severity [8]. Intrafamilial variability of disease phenotype and severity was notable in the largest Autosomal Dominant family [9]. It causes a wide spectrum of human diseases, including fifth disease (erythema infectiosum) in Children and pure red cell aplasia in immunocompromised patients [10].

B19V is highly erythrotropic and preferentially replicates in erythroid progenitor Cells (EPCs) [11]. In this article we propose a possible model for parvovirus B19 association with Systemic lupus erythematosus (SLE) [12]. Haematological manifestations are dominated by transient aplasia of erythroid progenitor Cells which remains asymptomatic in most of non immunocompromised patients [13]. He was transfused with packed red cells and treated with ganciclovir and intravenous immunoglobulin (IVIG) [14]. According to WHO, it is the fifth disease in the world (in years of illness), the second for people aged 15 to 44 and by 2020, it could become the second in the whole world population after cardiovascular diseases [15].

Although increasingly safer and more efficient antidepressants are available, physicians are frequently confronted with the problem of resistant depression [16]. Besides usual strategies such as lithium or thyroid hormones adding, some new approaches are now being used to improve the treatment of resistant depression [17]. Parvovirus B19 usually infects Children and causes the classic "slapped-cheek" rash of erythema infectiosum (fifth disease) [18]. Antibodies against parvovirus B19 were found in both samples, whereas viral DNA was absent in the serum [19]. The presence of DNA in aqueous humor samples shows, for the first time, persistence of parvovirus B19 in the eye in uveitis and also in healthy patients [20].

The second group included 184 pregnant Women and the third group consisted of 184 neonates, who were born to the Women in the second group [21]. Specific IgG and IgM antibodies to HPV B19 were measured using ELISA technique [22]. Treatment for PV B19-induced transient aplastic crisis is essentially supportive [23]. There may be a dilemma in patients on immunosuppressive therapy, since initially it is difficult to distinguish between Chronic pure red cell aplasia (a condition where intravenous immunoglobulin therapy is beneficial) and transient aplastic crisis, where supportive red cell transfusions suffice [24]. Both in Children and adults parvovirus B19 infections have been frequently implicated as a cause or trigger of various forms of autoimmune diseases affecting Joints, connective tissue and large and small vessels [25].

References: 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ,

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