DermKnowledgeBASE: Collodion

Collodion

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The text is the summary of recent articles on Collodion at 75 thresold from National Library of Medicine (NLM). This information is subject to NCBI's Disclaimer and Copyright notice.


Although most neonates with ARCI are collodion babies, the clinical presentation and severity of ARCI may vary significantly, ranging from harlequin ichthyosis, the most severe and often fatal form, to lamellar ichthyosis (LI) and (nonbullous) congenital ichthyosiform erythroderma (CIE) [1]. Infants with harlequin ichthyosis are usually born prematurely and are encased in thick, hard, armor-like plates of cornified skin that severely restrict movement [2]. Life-threatening complications in the immediate postnatal period include respiratory distress, feeding problems, and systemic infection [3]. Two-component signaling features autophosphorylation of a histidine kinase, followed by phosphotransfer to the receiver domain of a response regulator protein, which ultimately leads to an output response [4]. Autophosphorylation of the histidine kinase is responsive to the presence of a cognate environmental stimulus, thereby giving bacteria a means to detect and respond to changes in the environment [5].

Despite their importance in bacterial biology, histidine kinases remain poorly understood due to the inherent lability of phosphohistidine [6]. We have developed a nitrocellulose binding assay that can be used to characterize histidine kinases [7]. Most of our patients were born as collodion babies and showed a relatively mild Ichthyosis phenotype [8]. Therefore, it is possible to use the nitrocellulose for the blood-typing kit which leads to a simpler way to diagnose a blood type [9]. First, Antibody solutions and blood samples were sequentially absorbed on nitrocellulose strips, allowed to interact, rinsed with an isotonic solution and distilled water, and image processing performed on a digital picture of the remaining blood Cells [10].

Second, owing to the nonwicking property of the blood Cells on the hydrophobic nitrocellulose fibers, we employed another diagnostic criterion and investigated nitrocellulose blood-typing prototypes [11]. A 4th subtype has also been proposed: Pleomorphic Ichthyosis (PI), characterized by marked skin changes at birth and subsequently mild symptoms [12]. All of the infants underwent clinical, instrumental, and laboratory examinations, including IgM WB testing [13]. Pallidum antigens onto nitrocellulose sheets and incubating the strips with serum specimens from mother-child pairs [14]. During the heating elution procedure, we raised the temperature to reduce the intense vortexing time, and kept gentle rotating while precipitation to prevent nitrocellulose reformation [15].

The heating elution procedure achieved good technical reproducibility, and was much simpler and more efficient than the previous one [16]. Results showed that NC was detected, by its trimethylsilyl (TMS) derivatives, in all the explosive mixtures analyzed and no false positives were observed [17].

References: 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ,

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