DermKnowledgeBASE: Carcinoma Cuniculatum

Carcinoma Cuniculatum

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The text is the summary of recent articles on Carcinoma Cuniculatum at 75 thresold from National Library of Medicine (NLM). This information is subject to NCBI's Disclaimer and Copyright notice.

The histopathology was consistent with carcinoma cuniculatum, a rare, slow growing, verucciform variant of squamous cell carcinoma [1]. Histology of the Mass was defined as carcinoma cuniculatum with negative margins and no lymphovascular invasion [2]. Histological examination shows a proliferation of well-differentiated keratinocytes [3]. Clinical examination and radiological investigations suggested a chronic osteomyelitis and a first histological examination of a punch Biopsy was suggestive of a pseudo-epitheliomatous Hyperplasia [4]. Oral carcinoma cuniculatum is exceedingly rare, with very few reported cases in the English-language literature [5].

Classically, its presentation mimics osteomyelitis or a Dental abscess, resulting in misdiagnosis, multiple Biopsy examinations, and procedures before a final diagnosis of carcinoma cuniculatum [6]. Multiple Biopsy examinations were negative for malignancy, and the patient was misdiagnosed with osteomyelitis and dental abscess before obtaining an accurate diagnosis of carcinoma cuniculatum [7]. According to the latest studies, the sensitivity of the patients to TNF-alpha inhibitors could be genetically determined and may also be due to certain genetic polymorphisms of the NLP3 and CARD8 zones of the inflammasome [8]. This inevitably generates the hypothesis that within a certain group of patients the TNF-alpha inhibitors have some additional, and currently obscure, effects on presumably key regulatory proteins of the so-called extrinsic apoptotic pathway [9]. The present study describes the case of a patient who developed a rare form of skin Tumor - epithelioma cuniculatum - whilst undergoing Etanercept therapy for psoriatic arthritis [10].

The initial diagnosis of carcinoma cuniculatum is difficult and often delayed and can require repeated histopathologic evaluation by an experienced pathologist [11]. Oral carcinoma cuniculatum is an even rarer entity that is frequently misdiagnosed initially, a phenomenon described in about one-third of previously reported cases [12]. The present study was undertaken to determine if a previously observed common histologic pattern for carcinoma cuniculatum is diagnostically useful in esophageal Mucosal biopsy specimens [13]. Thirty-five esophageal Mucosal biopsies obtained from 25 procedures in 11 patients with a resection-proven diagnosis of carcinoma cuniculatum were compared with 92 esophageal biopsies from 69 patients with Benign diagnoses [14]. Pseudohyperplastic Carcinoma and carcinoma cuniculatum are both low-grade, extremely well-differentiated SCC variants characterized by an indolent clinical course and good prognosis [15].

Histopathologically, the point of differential diagnosis with other subtypes of OSCC included unique, cuniculatum architecture and branching crypts [16]. Because of its well-differentiated status, the prognosis of CC is usually optimistic [17]. We report 9 cases of esophageal carcinoma cuniculatum diagnosed on esophagectomy specimens in 7 men and 2 Women during a 20-year period [18]. All patients had an esophageal Mass or lesion on endoscopic examination [19]. Local resection was performed, and histological examination revealed the presence of well-differentiated SCC [20].

Additional hemi-mandibulectomy was performed and the final histological diagnosis was CC [21]. This case study describes a rare case of Oral carcinoma cuniculatum in a 7-year-old female [22]. Other SCC variants, such as carcinoma cuniculatum and pseudohyperplastic, adenosquamous and Acantholytic carcinomas, are rare [23]. It is described by an invasive growth pattern, but metastases to regional lymph nodes are rare [24]. Epithelioma cuniculatum presents as a slow growing Mass on the Plantar aspect of the Foot [25].

Finally, I will conclude that carcinoma cuniculatum as delineated by Aird and his colleagues is an extremely rare, indolent, nonmetastasizing squamous cell carcinoma composed of banal keratinocytes with unique clinical and histopathologic features that almost always arises on the Foot [26]. "Verrucous carcinoma" has also been used as a generic term under which are placed giant condyloma of Buschke-Loewenstein and carcinoma cuniculatum [27]. In this report morphological and immunohistological features in a rare case of carcinoma cuniculatum of the Oral cavity are described [28].

References: 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ,

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About Me

I have varied research interests ranging from eHealth, Health Information Exchange, Clinical Trials and Research, Contact Dermatitis, Bioinformatics, and Cosmetic Dermatology. I have work experience in Canada as an eHealth analyst, and in Dubai and India as a Specialist Dermatologist.


Bell Raj Eapen
Hamilton, ON