DermKnowledgeBASE: Actinic Keratosis

Actinic Keratosis

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The text is the summary of recent articles on Actinic Keratosis at 75 thresold from National Library of Medicine (NLM). This information is subject to NCBI's Disclaimer and Copyright notice.


In photodynamic therapy (PDT) the interaction of a photosensitizer (PS), light and oxygen leads to the formation of reactive oxygen species (ROS) and thus the selective Tumor Cells eradication [1]. Therefore, the use of PDT as a preventive treatment may constitute a very promising therapeutic modality for these syndromes [2]. We present two cases of Multiple sporadic, nonsyndromic BCCs, and one of these cases is a unique case of parotid invasion associated purely with actinic keratosis [3]. Surgical Excision of the lesions was performed, and the Biopsy results were squamous cell Carcinoma in situ and actinic Keratosis [4]. Dermatoscopy can be helpful in excluding signs of basal cell carcinoma when actinic keratosis is non-keratotic [5].

RESULTS: the actinic keratosis Lesion count decreased by an average of 76 percent compared with baseline [6]. Signs of photoaging were reduced significantly at the end of the study, with greater than 60 percent of the subjects reporting moderate or complete satisfaction with skin improvement [7]. Theranostics methods can provide Multiple benefits by inserting nanoparticles into the patient and using photodynamic therapy and pave the way for personalized medicine [8]. The present data suggest some treatment efficacy for subclinical AK lesions detected using RCM [9]. Total RNA was extracted from formalin fixed paraffin embedded biopsies of five stages along the malignant evolution of keratinocytes towards cSCC: Normal epidermis, solar elastosis, actinic Keratosis KIN1-2, advanced actinic keratosis KIN3 and well-differentiated cSCC [10].

The observed alterations focused in miRNAs involved in the regulation of AKT/mTOR or in those involved in epithelial to mesenchymal transition [11]. We found that it induces reversion of epithelial to mesenchymal transition [12]. Commercially available compounds such as 5-fluorouracil, ingenol mebutate, diclofenac sodium salt were also used in this study [13]. The effect of mentioned compounds on cell viability of squamous Carcinoma cell line and healthy keratinocytes was evaluated [14]. These results indicate bioactive properties of wool hydrolysates, which affect the viability of squamous Carcinoma Cells and decrease their Number [15].

Picato (ingenol mebutate) (LEO Pharma, Parsippany, NJ) gel was applied to an area with a known actinic keratosis daily for 3 days [16]. The Scale evaluated actinic keratosis, overall skin appearance, wrinkling, dyschromia, erythema, and texture [17]. Some lesions of BD are often difficult to be differentiated from seborrheic Keratosis, actinic keratosis, lichen planus-like keratosis, etc [18]. It has shown excellent therapeutic results in both Lesion and field-directed photodynamic therapy of actinic Keratosis (AK) [19]. Dermatoscopic non-melanoma patterns may have a comparable diagnostic value [20].

In this pilot study, facial lesions were collected retrospectively, resulting in a case set of 339 melanomas and 308 non-melanomas [21].

References: 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ,

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I have varied research interests ranging from eHealth, Health Information Exchange, Clinical Trials and Research, Contact Dermatitis, Bioinformatics, and Cosmetic Dermatology. I have work experience in Canada as an eHealth analyst, and in Dubai and India as a Specialist Dermatologist.

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