DermKnowledgeBASE: Actinic Keratosis

Actinic Keratosis

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The text is the summary of recent articles on Actinic Keratosis at 75 thresold from National Library of Medicine (NLM). This information is subject to NCBI's Disclaimer and Copyright notice.

Cutaneous invasive squamous cell carcinoma (inSCC) develops through precursor lesions, namely in situ squamous cell carcinoma (isSCC) and actinic Keratosis (AK), representing a natural model of carcinogenesis [1]. The most widely used is 5-aminolevulinic acid (ALA) which however, being a hydrophilic molecule, has difficultly penetrating the skin to achieve the desired therapeutic effect [2]. PARTICIPANTS: Participants included patients with 5 to 20 clinically typical actinic keratosis lesions on the full face/chest (250cm2), Scalp (25-250cm2), or the trunk/extremities (250cm2) [3]. CONCLUSION: Ingenol disoxate demonstrated adverse events and local skin reaction profiles similar to results seen in trials evaluating shorter two-day regimens and was effective in patients with actinic keratosis [4]. Optical coherence therapy demonstrated its reliability as a noninvasive mode of diagnosis for actinic keratosis as well as Actinic damage in the surrounding areas of field cancerization [5].

He is also a principle investigator for Michelson diagnostics [6]. An IRB-approved retrospective search of skin lesions diagnosed at University of Florida Oral and maxillofacial Pathology biopsy service between 1994 and 2015 was performed [7]. This study may help pathologists gain a better understanding of the frequency and variability of dermatologic lesions submitted to an Oral and maxillofacial Pathology Biopsy service and promote more interdisciplinary consultation within the field [8]. This study evaluated the incidence and scope of dermatologic lesions submitted to a large oral and maxillofacial Pathology Biopsy service over a long time period [9]. Further, in vitro kinase assay demonstrated that astragalin could directly bind to p38 MAPK and suppress p38 MAPK activity [10].

Nonmelanoma skin cancers (NMSCs), namely, basal cell carcinoma (BCC), squamous cell Carcinoma (SCC), and also actinic keratosis (AK), are the most common Malignant Tumors in humans [11].

References: 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ,

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About Me

I have varied research interests ranging from eHealth, Health Information Exchange, Clinical Trials and Research, Contact Dermatitis, Bioinformatics, and Cosmetic Dermatology. I have work experience in Canada as an eHealth analyst, and in Dubai and India as a Specialist Dermatologist.


Bell Raj Eapen
Hamilton, ON