DermKnowledgeBASE: Accessory Nipple

Accessory Nipple

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The text is the summary of recent articles on Accessory Nipple at 75 thresold from National Library of Medicine (NLM). This information is subject to NCBI's Disclaimer and Copyright notice.

We also came across a rare entity, accessory breast and accessory nipples [1]. After Excision, the Pathology report noted pilosebaceous units and smooth Muscle bundles, consistent with an accessory nipple [2]. In addition, the patient had another accessory nipple in the "milk line" on his torso [3]. Intraoperatively, a 14×10×8 cm accessory breast was found in the inframammary fold, distinct from the left breast and having an accessory nipple areola complex as well [4]. Ultrastructural features of Adult Epidermal nevi have rarely been investigated [5].

Herein, we report a case involving a Japanese Adult who had epidermal nevi with right congenital blindness and a right accessory nipple [6]. The histopathologic and ultrastructural studies showed divergent abnormal epidermal structures in both Melanocytes and keratinocytes [7]. A Number of cleft-like appearances (8/19) and central network-like structures (7/19) had also been observed [8]. We describe a 53-year-old man with an accessory nipple on the left Chest who presented with stage IIA testicular seminoma at the age of 47 [9]. Published reports of patients with polythelia and genitourinary malignancies, as well as other neoplasms, are reviewed [10].

The first case is developing normally but has severe limb anomalies, congenital constriction rings, scoliosis because of vertebral anomalies, a left accessory nipple, a small tumor-like Swelling on his lower back with tiny skin tubular appendages, a hypoplastic scrotum, and an anchored Penis [11]. The second case is developmentally delayed with limb malformations, congenital constriction rings, a lumbar myelomeningeocele, hemangioma, and tiny tubular skin appendages on the back [12]. We present a case of a 92-year-old Female with a 1-year history of a Subcutaneous Tumor of the right Axilla, histologically consistent with a diagnosis of PCDAA arising in an accessory nipple [13]. Peripheral streaks can also be seen in seborrheic keratosis and BCC [14]. The patient also exhibited Bilateral nipple retraction and Unilateral left-sided accessory nipple [15].

Dissension has arisen, with some dermatopathologists asserting that sclerotic fibroma is just an evolutionary end-point of a previous Lesion [16]. We detail the histopathological findings of lesions consistent with the classic description of SFS and compare these to sclerotic changes observed in an intradermal nevus, blue nevus, erythema elevatum diutinum, neurofollicular hamartoma, angiofibroma, neurofibroma, accessory nipple, and dermatofibromas [17]. Of the many forms, the most common is an accessory nipple, polythelia [18]. While familial polythelia is recognized, it is extremely rare [19]. In the past several years, polythelia has been noted to be associated with nephrourological anomalies [20].

All reports of such a relationship are in random, nonfamilial cases of polythelia [21]. We report three cases of polythelia in a family over two generations who had no urinary tract abnormalities [22]. Discussion includes a comprehensive review of familial polythelia and its association with Renal anomalies [23]. We report the first case in an adolescent female with an accessory nipple [24]. Whereas, 229 out of 3606 rats had one accessory nipple each, 9 animals had 2 accessories, and 3 females were deficient of the pectoral nipple [25].

Most of the accessory nipples were found either in the caudal and cranial regions of the third pectoral nipples or in the regions between the second and third abdomino-inguinal nipples [26]. In 208 out of 791 litters examined, 177 litters had only one sister-mate with accessory nipple, 29 litters had 2 sister-mates with accessories, and 2 litters had 3 sister-mates with accessories, respectively [27]. The localization of accessory nipples of the sister mates within the litter was similar in most of the cases [28]. The most common lesion was adenoma or florid papillomatosis (11 cases) [29].

References: 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ,

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I have varied research interests ranging from eHealth, Health Information Exchange, Clinical Trials and Research, Contact Dermatitis, Bioinformatics, and Cosmetic Dermatology. I have work experience in Canada as an eHealth analyst, and in Dubai and India as a Specialist Dermatologist.


Bell Raj Eapen
Hamilton, ON