DermKnowledgeBASE: 20 nail dystrophy

20 nail dystrophy

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The text is the summary of recent articles on 20 nail dystrophy at 75 thresold from National Library of Medicine (NLM). This information is subject to NCBI's Disclaimer and Copyright notice.

Isolated recessive Nail Dysplasia (IRND) is much rarer but has recently been recognized as a condition resulting in 20-nail Dystrophy in the absence of other cutaneous or extracutaneous findings [1]. We report a case of a 7-year-old girl with a 3-year history of 20-nail Dystrophy and no associated diseases or family history of skin or nail diseases [2]. He developed 20-nail Dystrophy that was recalcitrant to Antifungal and anti-inflammatory treatments [3]. Physical examination showed Lichenoid Papules that coalesced into large Plaques that were studded with milia over the pretibial areas and 20 Nail Dystrophy [4]. Pretibial epidermolysis bullosa is a rare variant of dystrophic epidermolysis bullosa that shows appreciable clinical overlap with dystrophic epidermolysis bullosa pruginosa [5].

Nail involvement with mycosis fungoides has been scarcely reported, but when present ranges from 20-nail Dystrophy to yellow discoloration [6]. It may involve only 1 or as many as 20 nails (20-nail dystrophy) [7]. It can be a manifestation of lichen planus, psoriasis, alopecia areata, immunoglobulin A Deficiency, atopic dermatitis, and ichthyosis vulgaris [8]. Nail matrix Biopsy results and physical examination findings help in establishing the cause of this condition, though often trachyonychia is an isolated finding [9]. When trachyonychia occurs in childhood as a manifestation of lichen planus, it tends to resolve with time [10].

This persists unchanged 6 years later, and she has no other evidence of any other cutaneous disease, nor a family history of IP or Nail Dystrophy [11]. The 2 Children with 20-nail Dystrophy improved without any therapy [12]. An 11-year-old boy had a two-month history of Nail dystrophy affecting all the fingernails and the great toenails [13]. A band-like Lymphocytic infiltrate was present in the superficial Dermis, and the basal Layer showed vacuolar alterations [14]. Because of the rarity of this disorder, and controversy surrounding its cause and pathogenesis, we share our experience with five patients whose clinical diagnoses were consistent with 20-nail Dystrophy [15].

Trachyonychia is a polyetiological symptom: psoriasis vulgaris, lichen planus, Alopecia areata, atopic Dermatitis, 20-nail Dystrophy of childhood, and severe Nail Dystrophy can all lead to trachyonychia-like Nail changes [16]. In our patients, lichen planus, or psoriasis were excluded clinically and histologically [17].

References: 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 ,

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About Me

I have varied research interests ranging from eHealth, Health Information Exchange, Clinical Trials and Research, Contact Dermatitis, Bioinformatics, and Cosmetic Dermatology. I have work experience in Canada as an eHealth analyst, and in Dubai and India as a Specialist Dermatologist.


Bell Raj Eapen
Hamilton, ON