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Varicose Veins

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The text is the summary of recent articles on Varicose Veins at 75 thresold from National Library of Medicine (NLM). This information is subject to NCBI's Disclaimer and Copyright notice.

Mention should be made that both Russian and foreign phlebologists along with an open Surgical operation on veins have more and more often been using minimally invasive endovenous techniques in comprehensive management of patients presenting with varicose veins [1]. This is accompanied and followed by demonstrating advantages of these techniques, describing the immediate and remote results obtained, as well as possible complications, both typical and rarely occurring [2]. Methods Full lower limb duplex ultrasonography revealed significant pelvic contribution in eight males presenting with Bilateral lower limb varicose veins [3]. Subsequently, all patients received pelvic vein embolisation, prior to Leg varicose vein treatment [4]. Foam sclerotherapy had a lower incidence of VTE compared to other procedures at 30 days, but this effect did not persist at 90 days or at one year [5].

Among various Surgical treatments for varicose veins, Cryosurgery of GSV is an alternative minimally invasive technique that could leave fewer scars and replace conventional stripping with ambulatory phlebectomy [6]. The patients were followed for postoperative complication with surveillance of Recurrence [7]. This patient has since completed the reminder of her lower limb varicose vein treatment [8]. Previous work describing overall trends and outcomes of varicose vein procedures across the United States demonstrates a benefit from these procedures [9]. These products and the combination VE-PY better improved PO 2 and PCO 2 [10].

The high prevalence of LEVV as a whole and its younger onset in recent decades cause more attention to an investigation of the relationship between the development of varicose veins, in childhood and adolescence in particular, and genomic changes [11]. Patients with varicose veins have been noted to have a genetically reduced capacity for contraction of the smooth Muscle Cells of the vein walls, their remodeling due to the increased synthesis of matrix Gla protein, overproduction of TGF-β1, a matrix metalloproteinase inhibitor, hyperhomocysteinemia, and Mutations in the genes encoding the synthesis of thrombomodulin [12]. Patients underwent standardized assessment with venous duplex ultrasonography, and completed questionnaires assessing quality of life (QoL) and symptoms (Aberdeen Varicose Vein Questionnaire, EuroQol Five Domain QoL assessment and EuroQol visual analogue scale) [13]. In both groups, duplex Ultrasound of the veins of the pelvis and lower Extremities was used to confirm the presence of varicose veins, identify any retrograde flow, accurately determine vein diameter, and to reveal any anatomical feature of the intrapelvic veins [14]. The aim of this study is to compare the effects of various therapeutic strategies among patients with varicose veins to Surgical ligation and vein stripping on the basis of quality of life [15].

Methods PubMed/Medline and Scopus databases were systemically searched from 1 January 2000 until 23 December 2015 for studies reporting outcome on the quality of life of different treatment techniques for varicose veins [16]. Endovenous techniques allow safer and more efficient treatment of certain particular conditions : small saphenous vein, Ulcers, and recurrent varicose veins [17]. Methods The superoxide dismutase, reduced glutathione (GSH) and total antioxidant status were measured with commercially available colorimetric kits in erythrocytes, plasma and varicose vein wall of 65 patients (second degree of clinical state classification, etiology, anatomy and pathophysiology) aged 22-70 (49 Women, 16 men) in comparison to normal great saphenous vein walls collected from 10 patients who underwent coronary artery bypass graft and blood collected from 20 healthy individuals [18]. There have been no significant changes in the concentration of GSH in plasma and in varicose vein [19]. Our results indicate impaired antioxidant defense mechanism in the blood of varicose vein patients [20].

No venous malformations except for varicose veins were revealed in the limbs or pelvis [21]. An extensive literature search was conducted in Medline using the following key words algorithm: ("Chronic venous disease" OR "Chronic venous insufficiency" OR "varicose veins") AND ("endothelial dysfunction" OR "inflammation") [22]. Endothelial dysfunction may be the central player in the link between varicose veins and deep vein thrombosis [23]. There was consensus towards using endothermal ablation for Truncal reflux, towards UGFS for localised varicose veins and towards conventional Surgery for large, extensive, Bilateral veins [24]. But, recanalization of the ablated varicose veins and phlebitis are common postoperative complications that jeopardize its clinical effects [25].

We hypothesize that ligation of the ablated varicose veins after FS will improve the outcomes of patients with varicose veins and venous Ulcer [26]. These procedures have high rates of success with scarce complications [27]. Ulcer Recurrence was less frequent in patients without concomitant deep venous reflux and in those treated with phlebectomy of varicose veins at the time of EVTA [28]. Presentation, Symptom severity, and response to treatment of pelvic source varicose veins are not Well Defined [29]. Both pelvic source varicose veins and saphenous incompetence were identified by duplex Ultrasound [30].

As it is poorly associated with patient-reported discomfort, the rVCSS is a poor tool for evaluating pelvic source varicose veins [31].

References: 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ,

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I have varied research interests ranging from eHealth, Health Information Exchange, Clinical Trials and Research, Contact Dermatitis, Bioinformatics, and Cosmetic Dermatology. I have work experience in Canada as an eHealth analyst, and in Dubai and India as a Specialist Dermatologist.


Bell Raj Eapen
Hamilton, ON