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Summary - Cryoglobulinemic Purpura

The text is the summary of recent articles on Cryoglobulinemic Purpura from National Library of Medicine (NLM). This information is subject to NCBI's Disclaimer and Copyright notice.

Anti-neutrophil cytoplasmic antibody (ANCA) -associated vasculitis (AAV) and cryoglobulinemic vasculitis (CV) rarely coexist. Cryoglobulins are produced by the over-stimulated immune system of patients with hepatitis C virus (HCV). The purpose of the study - investigation the separate joint lesion in systemic vasculitis, their X-ray sonographic characteristics, the correlation of the articular syndrome severity with extra-articular manifestations of the diseases, as well as aspects of the arthritis pathogenesis in this category of patients. Rituximab (RTX) is established for the treatment of rheumatoid arthritis. Most emergencies in dermatology comprise a variety of entities with a usually benign course. Cryoglobulinemia can induce systemic vasculitis affecting various organs such as skin, peripheral nerves, and kidney. Cryoglobulinemia is thought to be a rare condition. Direct-acting antivirals (DAAs) dramatically improve the treatment of hepatitis C virus (HCV) infections. Vasculitis is a remarkable presentation of the extrahepatic manifestations of HCV. Purpuric lesions appear in acral distribution in a variety of conditions and often provide clues to the clinical diagnosis. Cryoglobulins (circulating immune complexes of polyclonal IgG, monoclonal IgM, and rheumatoid factor) are detected in the circulation of 40% to 60% of patients with chronic hepatitis C virus infection, and cryoglobulinemic vasculitis (CV) is observed in approximately 10% of patients. A 68-year-old man was admitted because of weakness of the left leg, dysesthesiae of the extremities and bilateral lower extremity purpura. Inflammation mediated by cells of the immune system and necrosis are the most striking features observed at the histologic level in patients with vasculitides, clinical entities classified according to pathologic findings involving different organs, to etiology, or to size of vessels involved. Cryoglobulinemic vasculitis (CV) related to Hepatitis-B Virus (HBV) is rare and its treatment is ill-defined.To describe clinical and treatment characteristics of HBV-related CV patients. Cryoglobulinemic vasculitis (CV) is a small-to-medium-vessel vasculitis that appears in 10-15 % of patients chronically infected with hepatitis C virus (HCV). A 63-year-old Japanese woman with Sjögren's syndrome and peripheral neuropathy was admitted for evaluation of purpura on her lower extremities. A 61-year-old man with bilateral purpura of the lower limbs and subsequent edema, was hospitalization after renal dysfunction developed. The skin is one of the organs most frequently involved in vasculitides.

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