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Summary - Chilblains

The text is the summary of recent articles on Chilblains from National Library of Medicine (NLM). This information is subject to NCBI's Disclaimer and Copyright notice.

Rowell syndrome is defined as the association between lupus erythematosus, erythema multiforme-like lesions and characteristic immunological changes including positive tests for rheumatoid factor, speckled antinuclear antibody, positive anti-Ro or anti-La antibodies. Human urine is currently the subject of biomedical investigations as a potential therapeutic resource and it continues to be used in remedies in different cultures and societies, including the Spanish culture. A previously healthy 5-year-old girl presented with acute onset of blue toes and red spots on the nose and fingers. Three prime repair exonuclease 1 degrades single and double stranded DNA with 3'-5' nuclease activity and its mutations are related to type 1 IFN mediated autoinflammation due to accumulated intracellular nucleic acids. Takayasu arteritis, fibromuscular dysplasia (FMD), spontaneous arterial dissection, Raynaud's phenomenon, and chilblains are vascular conditions that are associated with an increased predisposition in women and are often underdiagnosed. Familial chilblain lupus belongs to the group of type I interferonopathies and is characterized by typical skin manifestations and acral ischaemia. The signaling adapter protein STING is crucial for the host immune response to cytosolic DNA and cyclic dinucleotides. Foot complaints have been shown to be common in systemic lupus erythematosus (SLE) and heterogeneous in nature. Human urine is currently the subject of biomedical investigations as a potential therapeutic resource and it continues to be used in remedies in different cultures and societies, including the Spanish culture. Familial chilblain lupus belongs to the group of type 1 interferonopathies and is particularly characterized by typical skin manifestations and ischemia of the acra. Aicardi-Goutières syndrome (AGS) is one of the expanding group of inherited congenital infection like syndromes. Approximately, 140 million people worldwide live permanently at high altitudes (HAs) and approximately another 40 million people travel to HA area (HAA) every year for reasons of occupation, sports or recreation. GPs prescribe topical corticosteroids to patients with chronic chilblains despite poor evidence for their effectiveness. Equestrian cold panniculitis has been described since 1980 in horse riders or in stable employees. Nifedipine is commonly prescribed for the treatment of chilblains (pernio, perniosis) on the basis of observational studies and a single small, older clinical trial.

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