<sbml xmlns="http://www.sbml.org/sbml/level2" level="2" version="1">
   <model id="SLOS - Cholesterol Biosynthesis" name="SLOS - Cholesterol Biosynthesis">
      <listOfCompartments>
         <compartment id="External_Species"/>
         <compartment id="Internal_Species"/>
      </listOfCompartments>
      <listOfSpecies>
         <species id="SQ" name="squalene" boundaryCondition="false" compartment="Internal_Species"/>
         <species id="ESQ" name="2,3-Epoxysqualene" boundaryCondition="false" compartment="Internal_Species"/>
         <species id="H2O" name="Water" boundaryCondition="true" compartment="External_Species"/>
         <species id="O2" name="Oxygen" boundaryCondition="true" compartment="External_Species"/>
         <species id="NADP" name="NADP" boundaryCondition="true" compartment="External_Species"/>
         <species id="NADPH" name="NADPH" boundaryCondition="true" compartment="External_Species"/>
         <species id="FORMATE" name="FORMATE" boundaryCondition="true" compartment="External_Species"/>
         <species id="CO2" name="CO2" boundaryCondition="true" compartment="External_Species"/>
         <species id="LA" name="Lanosterol" boundaryCondition="false" compartment="Internal_Species"/>
         <species id="C_8_24_DIEN" name="4,4-dimethyl-14a-hydroxymethyl-5a-cholesta-0,24-dien-3b-ol" boundaryCondition="false" compartment="Internal_Species"/>
         <species id="F_C_8_24_DIEN" name="4,4-dimethyl-14a-formyl-5a-cholesta-8,24-dien-3b-ol" boundaryCondition="false" compartment="Internal_Species"/>
         <species id="C_8_14_24_TRIEN" name="4,4-dimethyl-5-a-cholesta-8,14,24-trien-3-b-ol" boundaryCondition="false" compartment="Internal_Species"/>
         <species id="C5_8_24_DIEN" name="4,4-dimethyl-5a-cholesta-8,24-dien-3-b-ol" boundaryCondition="false" compartment="Internal_Species"/>
         <species id="HMC_8_24_DIEN" name="4a-hydroxymethyl-4b-methyl-5a-cholesta-8,24-dien-3b-ol" boundaryCondition="false" compartment="Internal_Species"/>
         <species id="FMC_8_24_DIEN" name="4a-fonnyl-4b-methyl-5a-cholesta-8,24-dien-3b-ol" boundaryCondition="false" compartment="Internal_Species"/>
         <species id="CMC_8_24_DIEN" name="4a-carboxy-4b-methyl-5a-cholesta-8,24-dien-3b-ol" boundaryCondition="false" compartment="Internal_Species"/>
         <species id="MC_8_24_DIEN_ON" name="4a-methyl-5a-cholesta-8,24-dien-3-one" boundaryCondition="false" compartment="Internal_Species"/>
         <species id="MZ" name="4-a-methyl-zymosterol" boundaryCondition="false" compartment="Internal_Species"/>
         <species id="MC4_8_24_DIEN" name="4a-hydroxymethyl-5a-cholesta-8,24-dien-3b-ol" boundaryCondition="false" compartment="Internal_Species"/>
         <species id="FC_8_24_DIEN" name="4a-formyl-5a-cholesta-8,24-dien-3b-ol" boundaryCondition="false" compartment="Internal_Species"/>
         <species id="CC_8_24_DIEN" name="4a-carboxy-5a-cholesta-8,24-dien-3b-ol" boundaryCondition="false" compartment="Internal_Species"/>
         <species id="C5_8_24_DIEN_ON" name="5a-cholesta-8,24-dien-3-one" boundaryCondition="false" compartment="Internal_Species"/>
         <species id="Z" name="zymosterol" boundaryCondition="false" compartment="Internal_Species"/>
         <species id="C_7_24_DIEN" name="5a-cholesta-7,24-dien-3b-ol" boundaryCondition="false" compartment="Internal_Species"/>
         <species id="L" name="lathosterol" boundaryCondition="false" compartment="Internal_Species"/>
         <species id="DHC7" name="7-dehydro-cholesterol" boundaryCondition="false" compartment="Internal_Species"/>
         <species id="C" name="cholesterol" boundaryCondition="true" compartment="External_Species"/>
         <species id="CYA" name="cycloartenol" boundaryCondition="false" compartment="Internal_Species"/>
         <species id="DHD7" name="7-dehydro-desmosterol" boundaryCondition="false" compartment="Internal_Species"/>
         <species id="D" name="desmosterol" boundaryCondition="false" compartment="Internal_Species"/>
         <species id="DHL" name="24,25-dihydro-lanosterol" boundaryCondition="false" compartment="Internal_Species"/>
         <species id="EN_8" name="4-a-methylcholesta-8-en-3b-ol" boundaryCondition="false" compartment="Internal_Species"/>
         <species id="M" name="mestenol" boundaryCondition="false" compartment="Internal_Species"/>
         <species id="E" name="Ergosterol" boundaryCondition="true" compartment="External_Species"/>
         <species id="P" name="Phytosterol" boundaryCondition="true" compartment="External_Species"/>
         <species id="DHC8" name="8-dehydro-cholesterol" boundaryCondition="false" compartment="Internal_Species"/>
         <species id="EN8OL" name="cholesta-8-en-3b-ol" boundaryCondition="false" compartment="Internal_Species"/>
         <species id="TRIEN_11" name="D-5,7,9(11)-trien" boundaryCondition="true" compartment="External_Species"/>
         <species id="H2O2" name="H2O2" boundaryCondition="true" compartment="External_Species"/>
         <species id="NOR_10_19" name="d5,7,9(10)trien-nor" boundaryCondition="true" compartment="External_Species"/>
         <species id="VITD3" name="vitd3" boundaryCondition="true" compartment="External_Species"/>
         <species id="FDP" name="2-trans,trans-farnesyl-diphosphate" boundaryCondition="true" compartment="External_Species"/>
         <species id="PSQ" name="presqualene-diphosphate" boundaryCondition="false" compartment="Internal_Species"/>
         <species id="DIPHOSPHATE" name="diphosphate" boundaryCondition="true" compartment="External_Species"/>
      </listOfSpecies>
      <listOfReactions>
         <reaction id="R3" reversible="false">
            <listOfReactants>
               <speciesReference species="SQ" stoichiometry="1"/>
               <speciesReference species="O2" stoichiometry="1"/>
               <speciesReference species="NADPH" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="ESQ" stoichiometry="1"/>
               <speciesReference species="H2O" stoichiometry="1"/>
               <speciesReference species="NADP" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R4" reversible="false">
            <listOfReactants>
               <speciesReference species="ESQ" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="LA" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R5" reversible="false">
            <listOfReactants>
               <speciesReference species="O2" stoichiometry="1"/>
               <speciesReference species="NADPH" stoichiometry="1"/>
               <speciesReference species="LA" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="H2O" stoichiometry="1"/>
               <speciesReference species="NADP" stoichiometry="1"/>
               <speciesReference species="C_8_24_DIEN" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R6" reversible="false">
            <listOfReactants>
               <speciesReference species="O2" stoichiometry="1"/>
               <speciesReference species="NADPH" stoichiometry="1"/>
               <speciesReference species="C_8_24_DIEN" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="H2O" stoichiometry="2"/>
               <speciesReference species="NADP" stoichiometry="1"/>
               <speciesReference species="F_C_8_24_DIEN" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R7" reversible="false">
            <listOfReactants>
               <speciesReference species="O2" stoichiometry="1"/>
               <speciesReference species="NADPH" stoichiometry="1"/>
               <speciesReference species="F_C_8_24_DIEN" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="H2O" stoichiometry="1"/>
               <speciesReference species="NADP" stoichiometry="1"/>
               <speciesReference species="FORMATE" stoichiometry="1"/>
               <speciesReference species="C_8_14_24_TRIEN" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R8" reversible="false">
            <listOfReactants>
               <speciesReference species="NADPH" stoichiometry="1"/>
               <speciesReference species="C_8_14_24_TRIEN" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="NADP" stoichiometry="1"/>
               <speciesReference species="C5_8_24_DIEN" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R9" reversible="false">
            <listOfReactants>
               <speciesReference species="O2" stoichiometry="1"/>
               <speciesReference species="NADPH" stoichiometry="1"/>
               <speciesReference species="C5_8_24_DIEN" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="H2O" stoichiometry="1"/>
               <speciesReference species="NADP" stoichiometry="1"/>
               <speciesReference species="HMC_8_24_DIEN" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R10" reversible="false">
            <listOfReactants>
               <speciesReference species="O2" stoichiometry="1"/>
               <speciesReference species="NADPH" stoichiometry="1"/>
               <speciesReference species="HMC_8_24_DIEN" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="H2O" stoichiometry="2"/>
               <speciesReference species="NADP" stoichiometry="1"/>
               <speciesReference species="FMC_8_24_DIEN" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R11" reversible="false">
            <listOfReactants>
               <speciesReference species="O2" stoichiometry="1"/>
               <speciesReference species="NADPH" stoichiometry="1"/>
               <speciesReference species="FMC_8_24_DIEN" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="H2O" stoichiometry="1"/>
               <speciesReference species="NADP" stoichiometry="1"/>
               <speciesReference species="CMC_8_24_DIEN" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R12" reversible="false">
            <listOfReactants>
               <speciesReference species="NADP" stoichiometry="1"/>
               <speciesReference species="CMC_8_24_DIEN" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="NADPH" stoichiometry="1"/>
               <speciesReference species="CO2" stoichiometry="1"/>
               <speciesReference species="MC_8_24_DIEN_ON" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R13" reversible="false">
            <listOfReactants>
               <speciesReference species="NADPH" stoichiometry="1"/>
               <speciesReference species="MC_8_24_DIEN_ON" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="NADP" stoichiometry="1"/>
               <speciesReference species="MZ" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R14" reversible="false">
            <listOfReactants>
               <speciesReference species="O2" stoichiometry="1"/>
               <speciesReference species="NADPH" stoichiometry="1"/>
               <speciesReference species="MZ" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="H2O" stoichiometry="1"/>
               <speciesReference species="NADP" stoichiometry="1"/>
               <speciesReference species="MC4_8_24_DIEN" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R15" reversible="false">
            <listOfReactants>
               <speciesReference species="O2" stoichiometry="1"/>
               <speciesReference species="NADPH" stoichiometry="1"/>
               <speciesReference species="MC4_8_24_DIEN" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="H2O" stoichiometry="2"/>
               <speciesReference species="NADP" stoichiometry="1"/>
               <speciesReference species="FC_8_24_DIEN" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R16" reversible="false">
            <listOfReactants>
               <speciesReference species="O2" stoichiometry="1"/>
               <speciesReference species="NADPH" stoichiometry="1"/>
               <speciesReference species="FC_8_24_DIEN" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="H2O" stoichiometry="1"/>
               <speciesReference species="NADP" stoichiometry="1"/>
               <speciesReference species="CC_8_24_DIEN" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R17" reversible="false">
            <listOfReactants>
               <speciesReference species="NADP" stoichiometry="1"/>
               <speciesReference species="CC_8_24_DIEN" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="NADPH" stoichiometry="1"/>
               <speciesReference species="CO2" stoichiometry="1"/>
               <speciesReference species="C5_8_24_DIEN_ON" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R18" reversible="false">
            <listOfReactants>
               <speciesReference species="NADPH" stoichiometry="1"/>
               <speciesReference species="C5_8_24_DIEN_ON" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="NADP" stoichiometry="1"/>
               <speciesReference species="Z" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R19" reversible="false">
            <listOfReactants>
               <speciesReference species="Z" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="C_7_24_DIEN" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R20" reversible="false">
            <listOfReactants>
               <speciesReference species="NADPH" stoichiometry="1"/>
               <speciesReference species="C_7_24_DIEN" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="NADP" stoichiometry="1"/>
               <speciesReference species="L" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R21" reversible="false">
            <listOfReactants>
               <speciesReference species="O2" stoichiometry="1"/>
               <speciesReference species="NADPH" stoichiometry="1"/>
               <speciesReference species="L" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="H2O" stoichiometry="1"/>
               <speciesReference species="NADP" stoichiometry="1"/>
               <speciesReference species="DHC7" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R22" reversible="false">
            <listOfReactants>
               <speciesReference species="NADPH" stoichiometry="1"/>
               <speciesReference species="DHC7" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="NADP" stoichiometry="1"/>
               <speciesReference species="C" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R23" reversible="false">
            <listOfReactants>
               <speciesReference species="ESQ" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="CYA" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R24" reversible="false">
            <listOfReactants>
               <speciesReference species="CYA" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="Z" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R25" reversible="false">
            <listOfReactants>
               <speciesReference species="C_7_24_DIEN" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="DHD7" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R26" reversible="false">
            <listOfReactants>
               <speciesReference species="DHD7" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="D" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R27" reversible="false">
            <listOfReactants>
               <speciesReference species="D" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="C" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R28" reversible="false">
            <listOfReactants>
               <speciesReference species="LA" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="DHL" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R29" reversible="false">
            <listOfReactants>
               <speciesReference species="C_8_24_DIEN" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="EN_8" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R30" reversible="false">
            <listOfReactants>
               <speciesReference species="DHL" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="EN_8" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R31" reversible="false">
            <listOfReactants>
               <speciesReference species="EN_8" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="M" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R32" reversible="false">
            <listOfReactants>
               <speciesReference species="M" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="L" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R33" reversible="false">
            <listOfReactants>
               <speciesReference species="D" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="E" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R34" reversible="false">
            <listOfReactants>
               <speciesReference species="D" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="P" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R35" reversible="true">
            <listOfReactants>
               <speciesReference species="DHC7" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="DHC8" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R39" reversible="true">
            <listOfReactants>
               <speciesReference species="L" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="EN8OL" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R40" reversible="false">
            <listOfReactants>
               <speciesReference species="EN8OL" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="DHC8" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R37" reversible="false">
            <listOfReactants>
               <speciesReference species="O2" stoichiometry="1"/>
               <speciesReference species="DHC7" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="TRIEN_11" stoichiometry="1"/>
               <speciesReference species="H2O2" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R36" reversible="false">
            <listOfReactants>
               <speciesReference species="DHC7" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="NOR_10_19" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R38" reversible="false">
            <listOfReactants>
               <speciesReference species="DHC7" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="VITD3" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R1" reversible="false">
            <listOfReactants>
               <speciesReference species="FDP" stoichiometry="2"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="PSQ" stoichiometry="1"/>
               <speciesReference species="DIPHOSPHATE" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
         <reaction id="R2" reversible="false">
            <listOfReactants>
               <speciesReference species="NADPH" stoichiometry="1"/>
               <speciesReference species="PSQ" stoichiometry="1"/>
            </listOfReactants>
            <listOfProducts>
               <speciesReference species="SQ" stoichiometry="1"/>
               <speciesReference species="NADP" stoichiometry="1"/>
               <speciesReference species="DIPHOSPHATE" stoichiometry="1"/>
            </listOfProducts>
         </reaction>
      </listOfReactions>
   </model>
</sbml>
